A Diagnostic Dilemma: High-Grade Appendiceal Mucinous Neoplasm Presenting as Acute Appendicitis in a 16-Year-Old Female - Case Report and Literature Review.

IF 0.7 Q4 GASTROENTEROLOGY & HEPATOLOGY

Case Reports in Gastroenterology Pub Date : 2026-01-13 eCollection Date: 2026-01-01 DOI:10.1159/000550074

Madhuri Singh, Charusheela Gore, Sushama Gurwale, Jhasnavi Mandala, Apoorva Makan

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Abstract

Introduction: High-grade appendiceal mucinous neoplasms (HAMNs) are rare mucin-producing epithelial tumors of the appendix, typically seen in middle-aged to elderly individuals. They are defined by high-grade cytologic atypia and complex architecture but without infiltrative invasion. Occurrence in pediatric or adolescent patients is virtually unknown.

Case presentation: We report a 16-year-old female who presented with signs and symptoms suggestive of acute appendicitis. Ultrasonography supported the diagnosis. A laparoscopic appendectomy was performed. Gross examination revealed a dilated appendix with mucoid contents. Histopathological evaluation confirmed HAMN confined to the appendix.

Conclusion: To our knowledge, this is the second reported case of HAMN in an adolescent. This case underscores the importance of histopathologic evaluation of all appendectomy specimens, even in young patients, due to the possibility of underlying neoplasia.

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诊断困境：16岁女性阑尾高级别黏液性肿瘤表现为急性阑尾炎病例报告及文献复习。

高级别阑尾黏液性肿瘤（HAMNs）是一种罕见的阑尾黏液生成上皮性肿瘤，常见于中老年人。它们以高度的细胞学非典型性和复杂的结构为特征，但没有浸润性侵袭。发生在儿童或青少年患者几乎是未知的。病例介绍：我们报告了一位16岁的女性，她表现出急性阑尾炎的体征和症状。超声检查证实了诊断。施行腹腔镜阑尾切除术。大体检查显示阑尾扩张伴黏液内容物。组织病理学检查证实HAMN局限于阑尾。结论：据我们所知，这是第二例报告的青少年HAMN病例。本病例强调了对所有阑尾切除术标本进行组织病理学评估的重要性，即使是年轻患者，因为可能存在潜在的肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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