Recent advances in plant polyphenol-based adhesive hydrogels for biomedical applications

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2026-06-01 Epub Date: 2026-02-03 DOI:10.1016/j.bioadv.2026.214757

Yajun Chen , Xue Guo , Yuxin Zhang , Zhenming Yang , Jinmin Meng , Peiying Li , Yeyan Ni , Zijuan Huang , Huiying Wu , Qufu Wei

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Abstract

Plant polyphenol-based hydrogels have gained widespread attention due to their unique and outstanding properties such as adhesion, antibacterial, self-healing and biocompatibility. The adhesion performance of these hydrogels can be systematically engineered to meet specific requirements, demonstrating significant potential in biomedical applications. This review initially explores the design strategies of hydrogels derived from different plant polyphenols. Subsequently, the multiple adhesive properties imparted by diverse design strategies, including dry adhesion, underwater adhesion, switchable adhesion, specific adhesion and asymmetrical adhesion are discussed. In addition, biomedical applications of plant polyphenol-based adhesive hydrogels, focusing on wound dressings, therapeutic drug delivery, cartilage tissue scaffolds and wearable electronics are summarized. In the end, remaining challenges and outline prospects for future research are discussed. It is hoped that this review can provide new innovation into the development of plant polyphenol-based adhesive hydrogels.

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生物医学用植物多酚基黏附水凝胶研究进展。

植物多酚类水凝胶因其独特的粘附性、抗菌性、自愈性和生物相容性而受到广泛关注。这些水凝胶的粘附性能可以系统地设计以满足特定要求，在生物医学应用中显示出巨大的潜力。本文初步探讨了由不同植物多酚衍生的水凝胶的设计策略。随后，讨论了不同设计策略所赋予的多种粘接性能，包括干粘接、水下粘接、可切换粘接、特定粘接和不对称粘接。此外，综述了植物多酚基黏附水凝胶在伤口敷料、治疗药物递送、软骨组织支架和可穿戴电子产品等方面的生物医学应用。最后，对未来研究面临的挑战和展望进行了讨论。希望本文的综述能够为植物多酚基黏附水凝胶的开发提供新的创新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!