Excitability prediction of the motor cortex leg representation using EEG-TMS

IF 3.4 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2026-04-01 Epub Date: 2026-02-03 DOI:10.1016/j.clinph.2026.2111694

Miriam Kirchhoff , Sarah Harders , David Emanuel Vetter , Maria Ermolova , Jiahua Xu , Ulf Ziemann

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引用次数: 0

Abstract

Objectives

Corticospinal excitability of the motor cortex (M1) hand representation is predicted by phase and power of the sensorimotor mu-rhythm in EEG-TMS studies. Here we address for the first time corticospinal excitability prediction of the M1 leg representation.

Methods

In 16 healthy subjects, 1,000 trials of single-pulse navigated focal TMS to the hot spot of the tibialis anterior muscle were obtained during motor evoked potential (MEP) and EEG recording, using Hjorth montages centered over sensorimotor cortex, ipsilateral to the hemisphere that was targeted by TMS.

Results

Power in the high gamma frequency bands correlated directly, and power in the beta band inversely with MEP amplitude. The phase of the mu-rhythm had no effect but a significant interaction between mu-power and mu-phase was observed: with high mu-power, largest MEPs occurred during the early peak, while with low mu-power largest MEPs were observed during the late peak.

Conclusions

Findings demonstrate that an interaction of mu-power and −phase, and power in other frequency bands of the EEG signal from the sensorimotor cortex prior to the TMS pulse predict corticospinal excitability of the M1 leg representation.

Significance

Findings may inform brain-state dependent stimulation of M1 leg representation for treatment of gait or balance disorders.

查看原文本刊更多论文

脑电-经颅磁刺激法预测运动皮层腿部表征的兴奋性。

目的：通过EEG-TMS研究中感觉-运动mu-节律的相位和功率来预测运动皮层（M1）手表征的皮质脊髓兴奋性。在这里，我们首次讨论了M1腿表征的皮质脊髓兴奋性预测。方法：选取16名健康受试者，在运动诱发电位（MEP）和脑电图（EEG）记录过程中，采用以感觉运动皮层为中心的Hjorth蒙太奇（Hjorth蒙太奇），在经颅磁刺激靶半球同侧，对胫骨前肌热点进行1000次单脉冲导航局灶性经颅磁刺激。结果：高频段功率与MEP幅值成正相关，高频段功率与MEP幅值成负相关。mu节律的相位没有影响，但在mu功率和mu相位之间观察到显著的相互作用：高mu功率时，最大的mep出现在高峰的早期，而低mu功率时，最大的mep出现在高峰的后期。结论：研究结果表明，在TMS脉冲之前，来自感觉运动皮层的脑电图信号的mu-功率和-相位以及其他频段的功率的相互作用预测了M1腿表征的皮质脊髓兴奋性。意义：研究结果可能为M1腿表征脑状态依赖性刺激治疗步态或平衡障碍提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.