The influence of a moderate versus high intensity training program on central pain processing: a pilot feasibility study.

Abstract

Background: This study evaluated the feasibility of two minimally equipped, blended supervised and tele-supported exercise programs, a moderate intensity training (MIT) and high intensity training (HIT) program, in healthy sedentary adults, and explored signals of efficacy on central pain processing.

Methods: Participants were randomized to a 10-week MIT or HIT program, each comprising one supervised group session and two tele-supported home-based sessions per week. MIT involved a Start-to-Run protocol at 60-70% of heart rate reserve, while HIT involved strength exercises at > 80% of predicted maximum heart rate. Feasibility outcomes included recruitment, retention, adherence, and acceptability. Quantitative sensory testing (QST) assessed central pain processing pre- and post-intervention.

Results: Eighteen participants were enrolled (8 MIT, 10 HIT). Retention was lower in the MIT group (5 completed) than the HIT group (11 completed), with high adherence in both. Participants appreciated the blended format but noted challenges with digital tools, and suggested refinements. No significant differences in QST outcomes were observed, likely due to small sample size and inter-individual variability. Individual responses suggested reduced pain inhibition following MIT and enhanced inhibition after HIT.

Conclusions: Both programs were feasible, supporting a larger-scale study to optimize implementation and confirm effects.

Clinical trial registration: ClinicalTrails.gov (ID: NCT06207422).