Erivaldo Machado Araújo, Hélio José Coelho-Júnior, Lana Passos Milhomem, Filipe Moura Ribeiro, Emanuele Marzetti, Thiago Dos Santos Rosa, Octávio Luiz Franco, Samuel da Silva Aguiar
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引用次数: 0
Abstract
Introduction: This study aimed to evaluate the effects of a 12-week dual-task resistance training (RT) program on inflammatory and metabolic biomarkers in institutionalized older adults and assess the impact of detraining.
Methods: The study followed a crossover experimental design. Participants were 11 older adults (mean age: 81.9 ± 3.0 years), who completed baseline (week 1), post-control (weeks 14-15), post-training (week 28), and post-detraining (week 42) assessments over 42 weeks. Immunometabolic markers, including interleukin (IL)-10, IL-18, IL-17, transforming growth factor-beta, sestrin-2, klotho, adiponectin, leptin, and irisin, were measured using enzyme-linked immunosorbent assay kits. A 12-week dual-task RT program (weeks 16-27) was carried out progressively, incorporating cognitive tasks during lower limb exercises. Cognitive complexity increased monthly, and detraining followed in weeks 29-41.
Results: Results demonstrated a significant post-training increase in IL-10 (p = 0.011) and a decrease in IL-18 (p < 0.001), indicating improved inflammatory status. Metabolic markers such as sestrin-2 (p = 0.016), klotho (p < 0.001), adiponectin (p = 0.019), and irisin (p = 0.009) also increased post training. Notably, klotho and irisin levels remained elevated post detraining, suggesting sustained benefits.
Conclusion: Dual-task RT enhanced inflammatory and metabolic profiles, partially retaining benefits after detraining. This intervention presents a viable strategy to mitigate aging-related systemic health decline in vulnerable populations.
期刊介绍：
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.
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