Clinical efficacy of Xifeng Huashi and its effect on mental status in patients with diarrheal irritable bowel.

IF 3.4 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2026-02-19 DOI:10.5498/wjp.v16.i2.113123

Wei Wang, Hui Li, Yu-Ping Liu, Yan Chen, Xiao-Ran Zhang, Yan-Zhou Wang, Yao-Zhou Tian

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引用次数: 0

Abstract

Background: Diarrheal irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder characterized by abdominal pain accompanied by recurrent diarrhea that significantly impacts the quality of life and mental health of patients.

Aim: To investigate the clinical efficacy of Xifeng Huashi and its effects on the mental status of patients diagnosed with IBS-D.

Methods: Data from 128 patients with IBS-D treated at the Nanjing University of Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine between June 2023 and May 2024 were divided into control and research groups, with 64 patients in each group. The control group received conventional treatment with Western medicine alone, whereas the research group was prescribed Xifeng Huashi. Differences in specific indices between the two groups were observed and compared using relevant assessment tools.

Results: The research group showed a higher total effective rate (92.19% vs 76.56%; P = 0.027) and lower traditional Chinese medicine symptom score (5.07 ± 3.11 vs 7.38 ± 3.68; P < 0.001) than the control group. Post-treatment, the research group exhibited significantly lower levels of pro-inflammatory cytokines (tumor necrosis factor-α: 18.80 ± 4.02 ng/L vs 21.09 ± 4.10 ng/L, P = 0.002; interleukin-6:14.84 ± 4.06 ng/L vs 19.80 ± 4.42 ng/L, P < 0.001) and higher levels of the anti-inflammatory cytokine interleukin-10 (48.53 ± 5.02 ng/L vs 46.06 ± 4.94 ng/L, P = 0.006). Moreover, markers of intestinal mucosal barrier function (diamine oxidase: 6.53 ± 2.35 ng/mL vs 7.66 ± 2.40 ng/mL, P = 0.008; D-lactate: 0.18 ± 0.04 mmol/L vs 0.20 ± 0.06 mmol/L, P = 0.004; lipopolysaccharides: 44.77 ± 8.16 pg/mL vs 48.20 ± 8.15 pg/mL, P = 0.019) were significantly improved in the research group. In addition, Self-rating Anxiety Scale (37.33 ± 5.73 vs 39.59 ± 6.36; P = 0.036) and Self-rating Depression Scale scores (34.77 ± 6.71 vs 38.06 ± 6.52; P = 0.006) were lower in the research group. The recurrence rate was significantly lower in the research group than in the control group (18.64% vs 40.82%, P = 0.001).

Conclusion: Xifeng Huashi is effective for the treatment of IBS-D and manifests advantages in improving clinical symptoms and mental status, as well as reducing the short-term relapse rate.

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泻风化湿对腹泻性肠易激患者精神状态的影响。

背景：腹泻性肠易激综合征（IBS-D）是一种以腹痛伴反复腹泻为特征的功能性胃肠道疾病，严重影响患者的生活质量和心理健康。目的：探讨西风化湿的临床疗效及其对IBS-D患者精神状态的影响。方法：选取2023年6月- 2024年5月南京中医药大学附属中西医结合医院治疗的IBS-D患者128例，分为对照组和研究组，每组64例。对照组给予常规西医治疗，研究组给予西风化食治疗。使用相关的评估工具，观察并比较两组间具体指标的差异。结果：研究组总有效率（92.19% vs 76.56%, P = 0.027）高于对照组，中医症状评分（5.07±3.11 vs 7.38±3.68,P < 0.001）低于对照组。治疗后，研究组促炎因子（肿瘤坏死因子-α: 18.80±4.02 ng/L vs 21.09±4.10 ng/L, P = 0.002；白细胞介素-6:14.84±4.06 ng/L vs 19.80±4.42 ng/L, P < 0.001）水平显著降低，抗炎因子白细胞介素-10水平显著升高（48.53±5.02 ng/L vs 46.06±4.94 ng/L, P = 0.006）。此外，肠道黏膜屏障功能指标（二胺氧化酶：6.53±2.35 ng/mL vs 7.66±2.40 ng/mL, P = 0.008； d -乳酸：0.18±0.04 mmol/L vs 0.20±0.06 mmol/L, P = 0.004；脂多糖：44.77±8.16 pg/mL vs 48.20±8.15 pg/mL, P = 0.019）均显著改善。此外，研究组焦虑自评评分（37.33±5.73比39.59±6.36,P = 0.036）和抑郁自评评分（34.77±6.71比38.06±6.52,P = 0.006）均低于对照组。研究组的复发率明显低于对照组（18.64% vs 40.82%, P = 0.001）。结论：西风化食治疗IBS-D有效，在改善临床症状和精神状态、降低短期复发率方面具有优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.