EFFECT OF PLATELET RICH FIBRIN ON WOUND HEALING TIME AFTER REVASCULARIZATION.

Abstract

One of the most common diseases in vascular surgery is peripheral arterial disease, the last stage of which is critical limb ischemia. It is characterized by rest pain or tissue loss. In most cases, after revascularization, and due to gangrenous changes, it is necessary to perform amputation of a part of the lower limb. After amputation, the wound is bandaged with dressings. In conducting this pilot study, some patients were bandaged with platelet rich fibrin (PRF) in combination with dressings, while the others were treated only with dressings. PRF is a biologic material that is received from blood of the patient. All patients included in the trial had at least 2 out of 3 traversable blood vessels in the lower leg before treatment and underwent femoropopliteal bridging with prosthesis. Patients treated with PRF after revascularization had an average of 5 weeks of wound healing, in contrast to patients treated only with dressings, whose mean wound healing was 8.5 weeks and a proportion of these patients ended up with an extended amputation level. After the study, it is concluded that this type of treatment can be safely used in the treatment of vascular pathology.