Effects of Light-Induced Electromagnetic Fields on Human Cancer Cells in Vitro.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Bioelectricity Pub Date : 2025-09-12 eCollection Date: 2025-09-01 DOI:10.1177/25763113251376255
Barbara Truglia, Sara Castria, Douglas Brown, Lew Lim, Bart de Wever, John Lewis, Jack Adam Tuszynski
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引用次数: 0

Abstract

Purpose: This study investigates two electromagnetic field (EMF) modalities on cancer cells: near-infrared pulsating light (NIR) and hyperpolarized light (HPL).

Methods: PC3, MCF7, and HeLa were exposed to Bioptron (HPL, 40 mW/cm2) and VieLight NeuroPro (NIR, 4.59 mW/cm2, 810 nm, 10 Hz) for 10-60 min, with intermittent breaks. Viability, cytoskeletal and mitochondrial morphology, ATP, and lactate levels were assessed.

Results: NIR primarily enhanced mitochondrial ATP production, while HPL induced early morphological changes. Both modalities showed exposure dependency on viability.

Conclusion: The analysis reveals distinct cellular responses to NIR and HPL, underscoring the importance of optimized protocols for effective EMF therapies.

光致电磁场对体外人癌细胞的影响
目的:研究近红外脉冲光(NIR)和超偏振光(HPL)两种电磁场(EMF)对癌细胞的作用。方法:PC3、MCF7和HeLa分别暴露于Bioptron (HPL, 40 mW/cm2)和VieLight NeuroPro (NIR, 4.59 mW/cm2, 810 nm, 10 Hz) 10-60 min,间歇休息。评估活力、细胞骨架和线粒体形态、ATP和乳酸水平。结果:NIR主要促进线粒体ATP的产生,而HPL诱导早期形态学改变。两种方式均显示暴露依赖于生存能力。结论:分析揭示了不同的细胞对NIR和HPL的反应,强调了优化方案对有效EMF治疗的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bioelectricity
Bioelectricity Multiple-
CiteScore
3.40
自引率
4.30%
发文量
33
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