{"title":"A multimodal approach to Canine Osteoarthritis management: A state-of-the-art.","authors":"Hithem Bougherara, Saïd Boukhechem, Amira Leila Dib","doi":"10.5455/OVJ.2025.v15.i11.3","DOIUrl":null,"url":null,"abstract":"<p><p>Canine osteoarthritis (OA) is a prevalent, progressive, and debilitating joint disorder characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling. This multifactorial disease leads to chronic pain and significant impairment of quality of life. As OA remains incurable, therapeutic strategies have shifted toward comprehensive multimodal management aimed at addressing the disease's complex pathophysiology. This review presents an evidence-based overview of current approaches, including weight management, rehabilitation, pharmacologic therapies (Non-Steroidal Anti-Inflammatory Drugs, anti-Nerve Growth Factor monoclonal antibodies), disease-modifying osteoarthritis drugs, regenerative treatments, and nutraceuticals. This study also highlights practical challenges and future directions, emphasizing individualized treatment plans to optimize outcomes in canine OA.</p>","PeriodicalId":19531,"journal":{"name":"Open Veterinary Journal","volume":"15 11","pages":"5461-5465"},"PeriodicalIF":1.0000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861432/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Veterinary Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/OVJ.2025.v15.i11.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Canine osteoarthritis (OA) is a prevalent, progressive, and debilitating joint disorder characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling. This multifactorial disease leads to chronic pain and significant impairment of quality of life. As OA remains incurable, therapeutic strategies have shifted toward comprehensive multimodal management aimed at addressing the disease's complex pathophysiology. This review presents an evidence-based overview of current approaches, including weight management, rehabilitation, pharmacologic therapies (Non-Steroidal Anti-Inflammatory Drugs, anti-Nerve Growth Factor monoclonal antibodies), disease-modifying osteoarthritis drugs, regenerative treatments, and nutraceuticals. This study also highlights practical challenges and future directions, emphasizing individualized treatment plans to optimize outcomes in canine OA.
期刊介绍：
Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.
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