Isolation and synthesis of bisabosquals, fungal triprenyl phenol meroterpenoids with a densely functionalised bisabolane core

IF 12.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2026-05-27 Epub Date: 2026-02-02 DOI:10.1039/d5np00085h

James P. Shephard , David W. Lupton

引用次数: 0

Abstract

Covering: up to 2026

The Stachybotrys fungi have proven to be rich sources of triprenyl meroterpenoids. In addition to natural products typified by the relatively well known K76, stachybotrin, kampanol and stachyflin are the bisabosquals. The first four bisabosquals were discovered in 2001 and found to have a unique molecular structure displaying an all cis benzopyran-fused benzofuran core. Over the past two decades, this family has been extended, while their novel structure has stimulated efforts focused on their chemical synthesis. Herein, we provide a highlight, covering the isolation, biosynthesis and bioactivities of the bisabosquals and seco-bisabosquals along with studies focused on their total syntheses.

Abstract Image

查看原文本刊更多论文

双角鲨的分离和合成，真菌三戊烯基苯酚二萜类具有密集功能化的双角鲨烷核心。

Stachybotrys真菌已被证明是三烯丙基二萜类化合物的丰富来源。除了以相对知名的K76为代表的天然产物外，stachybotrin， kampanol和stachyflin是双角鲨。最早的四个双角鲨是在2001年发现的，发现它们具有独特的分子结构，显示全顺式苯并吡喃-融合苯并呋喃核心。在过去的二十年中，这个家族已经扩展，而它们的新结构刺激了对其化学合成的努力。在此，我们将重点介绍双角鲨和次双角鲨的分离、生物合成和生物活性，以及它们的全合成研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.