Classification of Nonsystemic Juvenile Idiopathic Arthritis Using the Provisional Paediatric Rheumatology International Trials Organisation Criteria.

IF 3.7 2区医学 Q2 RHEUMATOLOGY

Journal of Rheumatology Pub Date : 2026-07-01 DOI:10.3899/jrheum.2025-0551

Mehmet Yildiz, Elif Kilic Konte, Esma Aslan, Nergis Akay, Hakan Demir, Aybuke Gunalp, Fatih Haslak, Umit Gul, Ece Aslan, Sezgin Sahin, Amra Adrovic, Kenan Barut, Ozgur Kasapcopur

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Abstract

Objective: This study aimed to retrospectively evaluate the provisional Paediatric Rheumatology International Trials Organisation (PRINTO) criteria in patients with juvenile idiopathic arthritis (JIA) classified according to the International League of Associations for Rheumatology (ILAR) criteria.

Methods: This retrospective cohort study was conducted at a single tertiary pediatric rheumatology center. In total, 310 patients with nonsystemic JIA were classified according to both ILAR and provisional PRINTO criteria. Demographic, clinical, and laboratory features were recorded, and the distribution of JIA categories under both classification systems was analyzed.

Results: The mean age at study enrollment was 169.8 (SD 59.2) months. Using ILAR criteria, 136 patients (43.9%) were categorized as having oligoarticular JIA, 73 (23.5%) enthesitis-related arthritis, 34 (11%) rheumatoid factor (RF)-negative polyarticular JIA, 12 (3.9%) psoriatic arthritis (PsA), 7 (2.3%) RF-positive polyarticular JIA, and 48 (15.5%) undifferentiated JIA. The provisional PRINTO criteria classified 107 (34.5%) patients with early-onset antinuclear antibody-positive JIA, 93 (30%) other JIA, 88 (28.4%) enthesitis/spondylitis-related JIA, 17 (5.5%) RF-positive JIA, and 5 (1.6%) unclassified JIA. The other JIA category included 93 patients, consisting of those with oligoarticular JIA (54.8%), RF-negative polyarticular JIA (21.5%), undifferentiated JIA (11.8%), enthesitis-related arthritis (6.5%), and PsA (5.4%) under the ILAR classification system.

Conclusion: The provisional PRINTO criteria successfully reclassified a substantial proportion of previously undifferentiated JIA cases, improving diagnostic categorization by addressing some ILAR classification limitations. However, the high number of patients in the other JIA group highlights a potential limitation of the new system, warranting further investigation.

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非全身性幼年特发性关节炎：临时PRINTO标准如何形成分类？

目的：本研究旨在回顾性评价根据国际风湿病协会联盟（ILAR）标准分类的儿童特发性关节炎（JIA）患者的临时儿科风湿病国际试验组织（PRINTO）标准。方法：本回顾性队列研究在单一三级儿科风湿病中心进行。共有310例非全身性JIA患者根据ILAR和临时PRINTO标准进行分类。记录人口统计学、临床和实验室特征，并分析两种分类系统下JIA类别的分布。结果：研究时平均年龄为169.8±59.2个月。根据ILAR标准，136例（43.9%）患者被归类为少关节型JIA， 73例（23.5%）为关节炎相关性关节炎，34例（11.0%）为rf阴性多关节型JIA， 12例（3.9%）为银屑病关节炎，7例（2.3%）为rf阳性多关节型JIA， 48例（15.5%）为未分化型JIA。暂定PRINTO标准将107例（34.5%）患者分类为早发性抗核抗体阳性JIA， 93例（30.0%）为其他JIA， 88例（28.4%）为骨髓炎/脊柱炎相关JIA， 17例（5.5%）为rf阳性JIA， 5例（1.6%）为未分类JIA。其他JIA类别包括93例患者，包括低关节JIA（54.8%）、rf阴性多关节JIA（21.5%）、未分化JIA（11.8%）、关节炎相关关节炎（6.5%）和银屑病关节炎（5.4%）。结论：临时PRINTO标准成功地重新分类了大量以前未分化的JIA病例，通过解决一些ILAR分类限制改善了诊断分类。然而，“其他JIA”组的大量患者突出了新系统的潜在局限性，需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Rheumatology 医学-风湿病学

CiteScore

6.50

自引率

5.10%

发文量

285

审稿时长

1 months

期刊介绍： The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.