Strategies for the multicomponent reaction facilitating the expedited synthesis of functionalized thiazolidinone scaffolds

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2026-02-01 Epub Date: 2025-12-09 DOI:10.1080/00397911.2025.2598622

Tanzeela Riaz (Data curation Formal analysis Investigation Methodology Validation Writing – original draft) , Matloob Ahmad (Conceptualization Funding acquisition Resources Supervision Writing – review & editing) , Hafiza Noor Fatima (Data curation Formal analysis Investigation) , Sumayya Akram (Methodology Project administration Validation) , Sana Aslam (Conceptualization Project administration Writing – review & editing)

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Abstract

Thiazolidinone is a saturated five-membered heterocyclic system that features sulfur and nitrogen at the 1 and 3 positions, as well as a carbonyl group. There are several derivatives of thiazolidinone which exist with varied positions of carbonyl groups. It is a well-recognized building block in many natural and medicinal compounds. Thiazolidinone derivatives exhibit a wide range of biological activities. The synthesis of thiazolidinone derivatives has gained significant attention in recent years due to the growing demand for heterocycles. Various strategies have been developed for the synthesis of thiazolidinones. In this review, we discuss several recent synthetic approaches, including catalyst-free, metal-based nano-catalyzed, acid-catalyzed, base-catalyzed, ionic liquid-assisted, and other processes employed in multicomponent reactions to form different thiazolidinone derivatives. These studies can help to further develop effective synthetic strategies for functionalized thiazolidinone derivatives.

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促进功能化噻唑烷酮支架快速合成的多组分反应策略

噻唑烷酮是一种饱和的五元杂环系统，在1和3位上具有硫和氮，以及羰基。噻唑烷酮有几种羰基位置不同的衍生物。它是许多天然和药用化合物中公认的组成部分。噻唑烷酮衍生物具有广泛的生物活性。近年来，杂环化合物的需求不断增加，噻唑烷酮衍生物的合成受到了广泛的关注。噻唑烷酮的合成方法多种多样。在这篇综述中，我们讨论了几种最近的合成方法，包括无催化剂、金属基纳米催化、酸催化、碱催化、离子液体辅助以及其他用于多组分反应的合成方法，以形成不同的噻唑烷酮衍生物。这些研究有助于进一步制定有效的功能化噻唑烷酮衍生物的合成策略。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.