{"title":"AI-empowered crop protection against insect-borne diseases","authors":"Pingzhi Zhao , Qiudong Xia , Jian Ye","doi":"10.1016/j.copbio.2026.103445","DOIUrl":null,"url":null,"abstract":"<div><div>Insect-borne plant diseases, such as psyllid-transmitted citrus Huanglongbing (HLB) and whitefly-transmitted viral diseases, pose a major threat to global agriculture. These insect-borne pathogens establish in multipartite interactions with host plants and insect vectors, frequently altering host physiology and vector behavior to facilitate transmission. This review examines recent advances in plant defense against these pathogens, as well as pathogen strategies that undermine host defenses. We emphasize the promise of artificial intelligence (AI) in accelerating scientific research and technological advancements for managing insect-borne diseases. These strategies contribute to building an integrated platform, which trains scientific foundation models and creates AI agents to automate research workflows and test hypotheses. They also provided precision intervention strategies by identifying resistance genes, developing <em>in silico</em> approaches to develop new pesticides, and synthetic immune proteins. These AI platforms for insect-borne plant diseases enable a systemic understanding of the complex pathogen–plant–insect interactions, thereby offering new opportunities for controlling disease outbreaks and epidemics.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"98 ","pages":"Article 103445"},"PeriodicalIF":7.8000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0958166926000108","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Insect-borne plant diseases, such as psyllid-transmitted citrus Huanglongbing (HLB) and whitefly-transmitted viral diseases, pose a major threat to global agriculture. These insect-borne pathogens establish in multipartite interactions with host plants and insect vectors, frequently altering host physiology and vector behavior to facilitate transmission. This review examines recent advances in plant defense against these pathogens, as well as pathogen strategies that undermine host defenses. We emphasize the promise of artificial intelligence (AI) in accelerating scientific research and technological advancements for managing insect-borne diseases. These strategies contribute to building an integrated platform, which trains scientific foundation models and creates AI agents to automate research workflows and test hypotheses. They also provided precision intervention strategies by identifying resistance genes, developing in silico approaches to develop new pesticides, and synthetic immune proteins. These AI platforms for insect-borne plant diseases enable a systemic understanding of the complex pathogen–plant–insect interactions, thereby offering new opportunities for controlling disease outbreaks and epidemics.
期刊介绍:
Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time.
As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows.
COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.