Assessment of phase-locking factor with visual area-targeted transcranial magnetic stimulation-electroencephalography shows reduced connectivity in schizophrenia: A preliminary study

IF 2.4 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI:10.1016/j.pscychresns.2026.112153

Masayuki Ide , Akihiro Tadamura , Takehiro Miyazaki , Yoshiki Inoue , Aya Sekine , Takumi Takahashi , Masashi Tamura , Asaki Matsuzaki , Kiyotaka Nemoto , Hirokazu Tachikawa , Tetsuaki Arai , Masahiro Kawasaki

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引用次数: 0

Abstract

As pathophysiological mechanisms of schizophrenia remain unclear, the development of reliable biomarkers for the disease is highly anticipated. Electroencephalogram with transcranial magnetic stimulation (TMS-EEG) is a developing technique for assessing mental condition. Phase-locking factors (PLFs) are a parameter of phase synchronization, which can assess the brain connectivity of specific areas. Both visual processing impairments and aberrant brain connectivity are implicated in the pathophysiology of schizophrenia. Here, we compared motor area PLFs using visual area-targeted TMS-EEG between three groups: 15 patients with schizophrenia (SZ), 15 patients with major depressive disorder (MD), and 15 healthy controls (HC). The PLF of the SZ group showed a significant decrease in the theta band compared to the HC group without confounding effects from TMS click noises or antipsychotic medication. The reduction of PLF in the theta band between the visual and motor area could reflect visual processing impairments in schizophrenia. Further experiments with larger sample size and appropriate cognitive tasks are required to confirm our conclusion.

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用目视区域靶向经颅磁刺激-脑电图评估锁相因子显示精神分裂症患者连通性降低：一项初步研究

由于精神分裂症的病理生理机制尚不清楚，因此对该疾病的可靠生物标志物的开发备受期待。经颅磁刺激脑电图（TMS-EEG）是一种新兴的精神状态评估技术。锁相因子（PLFs）是相位同步的一个参数，可以评估大脑特定区域的连通性。视觉加工障碍和异常的脑连通性都与精神分裂症的病理生理有关。在这里，我们比较了三组：15名精神分裂症患者（SZ）， 15名重度抑郁症患者（MD）和15名健康对照（HC）的运动区PLFs，使用视觉区域靶向TMS-EEG。与HC组相比，SZ组的PLF在θ波段明显下降，没有TMS咔嗒声或抗精神病药物的混杂影响。视觉和运动区之间的θ波段PLF的减少可以反映精神分裂症的视觉加工障碍。进一步的实验需要更大的样本量和适当的认知任务来证实我们的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.