Sensory over-responsivity in obsessive-compulsive disorder: A systematic review and meta-analysis of case control studies

IF 2.1 4区医学 Q3 PSYCHIATRY

Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2026-01-01 Epub Date: 2026-01-10 DOI:10.1016/j.jocrd.2026.100994

Braeden Hysuick-Weik, Blake A.E. Boehme, Holden J. Norrie, Eric D. Tessier, Gordon J.G. Asmundson

{"title":"Sensory over-responsivity in obsessive-compulsive disorder: A systematic review and meta-analysis of case control studies","authors":"Braeden Hysuick-Weik, Blake A.E. Boehme, Holden J. Norrie, Eric D. Tessier, Gordon J.G. Asmundson","doi":"10.1016/j.jocrd.2026.100994","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Sensory over-responsivity (SOR) refers to distress experienced in response to ordinary sights, sounds, smells, and textures. This SOR has been found to be elevated in OCD. The current systematic review and meta-analysis assessed whether participants with OCD report higher SOR than healthy controls.</div></div><div><h3>Method</h3><div>Systematic searches were conducted in PsycINFO, PubMed, and Embase. The Newcastle-Ottawa Scale served as the tool for evaluating risk of bias. A random-effects meta-analysis was conducted using Hedges' <em>g</em> to estimate pooled effect sizes. Study heterogeneity was assessed using Cochran's <em>Q</em> and quantified with the <em>I</em><sup>2</sup> statistic. To evaluate the potential influence of unpublished or missing studies, Egger's regression was applied.</div></div><div><h3>Results</h3><div>A total of <em>k</em> = 6 studies (<em>N</em> = 376 OCD; <em>N</em> = 713 controls) met inclusion criteria. Participants with OCD exhibited significantly higher SOR compared to healthy controls (Hedges’ <em>g</em> = 1.73; 95 % CI [1.22, 2.24], <em>Z</em> = 6.62, <em>p</em> < .001; <em>I</em><sup>2</sup> = 76.2 %). An examination of the results for potential bias found no indication of missing or unpublished studies that might have influenced the findings. Risk of bias ratings showed the studies were of moderate to high quality.</div></div><div><h3>Discussion</h3><div>People with OCD show significantly higher SOR than healthy controls, suggesting that heightened sensitivity to external sensory stimuli may be relevant to OCD. Considerable heterogeneity, coupled with the small number of studies, raises some uncertainty about the generalizability of the results. Clinicians might consider SOR in case formulation. Further research is needed to gain a deeper understanding of SOR in other clinical populations.</div></div><div><h3>Registration</h3><div>CRD42024608769.</div></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":"48 ","pages":"Article 100994"},"PeriodicalIF":2.1000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obsessive-Compulsive and Related Disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211364926000011","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Sensory over-responsivity (SOR) refers to distress experienced in response to ordinary sights, sounds, smells, and textures. This SOR has been found to be elevated in OCD. The current systematic review and meta-analysis assessed whether participants with OCD report higher SOR than healthy controls.

Method

Systematic searches were conducted in PsycINFO, PubMed, and Embase. The Newcastle-Ottawa Scale served as the tool for evaluating risk of bias. A random-effects meta-analysis was conducted using Hedges' g to estimate pooled effect sizes. Study heterogeneity was assessed using Cochran's Q and quantified with the I² statistic. To evaluate the potential influence of unpublished or missing studies, Egger's regression was applied.

Results

A total of k = 6 studies (N = 376 OCD; N = 713 controls) met inclusion criteria. Participants with OCD exhibited significantly higher SOR compared to healthy controls (Hedges’ g = 1.73; 95 % CI [1.22, 2.24], Z = 6.62, p < .001; I² = 76.2 %). An examination of the results for potential bias found no indication of missing or unpublished studies that might have influenced the findings. Risk of bias ratings showed the studies were of moderate to high quality.

Discussion

People with OCD show significantly higher SOR than healthy controls, suggesting that heightened sensitivity to external sensory stimuli may be relevant to OCD. Considerable heterogeneity, coupled with the small number of studies, raises some uncertainty about the generalizability of the results. Clinicians might consider SOR in case formulation. Further research is needed to gain a deeper understanding of SOR in other clinical populations.

Registration

CRD42024608769.

查看原文本刊更多论文

强迫症的感觉过度反应：病例对照研究的系统回顾和荟萃分析

感官过度反应（SOR）是指对普通的视觉、声音、气味和纹理做出反应时所经历的痛苦。这种SOR在强迫症患者中已被发现升高。目前的系统回顾和荟萃分析评估了强迫症患者报告的SOR是否高于健康对照组。方法系统检索PsycINFO、PubMed、Embase。纽卡斯尔-渥太华量表是评估偏倚风险的工具。随机效应荟萃分析使用Hedges' g来估计合并效应大小。采用Cochran’s Q评价研究异质性，并采用I2统计量进行量化。为了评估未发表或缺失研究的潜在影响，应用了Egger回归。结果共有k = 6项研究（N = 376例强迫症患者，N = 713例对照组）符合纳入标准。与健康对照组相比，强迫症参与者表现出显著更高的SOR （Hedges ' g = 1.73; 95% CI [1.22, 2.24], Z = 6.62, p < .001; I2 = 76.2%）。对结果的潜在偏倚检查没有发现可能影响结果的缺失或未发表的研究的迹象。偏倚风险评级显示研究质量为中等至高。强迫症患者的SOR明显高于健康对照组，这表明对外部感官刺激的高度敏感性可能与强迫症有关。相当大的异质性，加上研究数量少，对结果的普遍性提出了一些不确定性。临床医生可能会在制定病例时考虑SOR。需要进一步的研究来更深入地了解SOR在其他临床人群中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Obsessive-Compulsive and Related Disorders PSYCHIATRY-

CiteScore

4.00

自引率

5.60%

发文量

审稿时长

47 days

期刊介绍： Journal of Obsessive-Compulsive and Related Disorders (JOCRD) is an international journal that publishes high quality research and clinically-oriented articles dealing with all aspects of obsessive-compulsive disorder (OCD) and related conditions (OC spectrum disorders; e.g., trichotillomania, hoarding, body dysmorphic disorder). The journal invites studies of clinical and non-clinical (i.e., student) samples of all age groups from the fields of psychiatry, psychology, neuroscience, and other medical and health sciences. The journal''s broad focus encompasses classification, assessment, psychological and psychiatric treatment, prevention, psychopathology, neurobiology and genetics. Clinical reports (descriptions of innovative treatment methods) and book reviews on all aspects of OCD-related disorders will be considered, as will theoretical and review articles that make valuable contributions. Suitable topics for manuscripts include: -The boundaries of OCD and relationships with OC spectrum disorders -Validation of assessments of obsessive-compulsive and related phenomena -OCD symptoms in diverse social and cultural contexts -Studies of neurobiological and genetic factors in OCD and related conditions -Experimental and descriptive psychopathology and epidemiological studies -Studies on relationships among cognitive and behavioral variables in OCD and related disorders -Interpersonal aspects of OCD and related disorders -Evaluation of psychological and psychiatric treatment and prevention programs, and predictors of outcome.