Schiff Base Compounds as Versatile Building Blocks for Drug Delivery Systems

IF 5.9 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2026-04-01 Epub Date: 2026-01-13 DOI:10.1016/j.inoche.2026.116193

Somaye Shahraki , Esmaeil Vaziri , Jing Ding , Kelong Fan

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引用次数: 0

Abstract

Despite the notable success of traditional therapeutic approaches such as chemotherapy, significant limitations remain, including high dosage requirements, drug resistance, nonselectivity, adverse side effects, and poor bioavailability. To address these challenges, drug delivery systems (DDSs) have been developed to more effectively transport therapeutic agents to target sites while minimizing systemic toxicity. Among the strategies for designing smart DDSs, reversible covalent interactions, particularly Schiff base linkages, have emerged as crucial components due to their dynamic and stimuli-responsive properties. In this review, we emphasize the role of Schiff base chemistry in DDSs, highlighting its structural advantages, responsiveness to physiological triggers (e.g., pH), and its contribution to enhanced therapeutic efficacy. We also examine the integration of Schiff base compounds into various polymeric DDS architectures and discuss recent advancements in their applications for selective and controlled drug release. Finally, we consider the current challenges and future directions for achieving precise, targeted drug delivery through Schiff base-based systems.

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希夫碱化合物作为药物传递系统的通用构件

尽管化疗等传统治疗方法取得了显著的成功，但仍存在显著的局限性，包括高剂量要求、耐药、非选择性、不良副作用和生物利用度差。为了应对这些挑战，人们开发了药物输送系统（dds），以更有效地将治疗剂输送到靶点，同时最大限度地减少全身毒性。在设计智能dds的策略中，可逆共价相互作用，特别是希夫碱键，由于其动态和刺激响应特性而成为关键组成部分。在这篇综述中，我们强调希夫碱化学在dss中的作用，强调其结构优势，对生理触发（如pH）的反应性，以及它对提高治疗效果的贡献。我们还研究了希夫碱化合物与各种聚合物DDS结构的整合，并讨论了它们在选择性和受控药物释放方面的应用的最新进展。最后，我们考虑了当前的挑战和未来的方向，以实现精确的，有针对性的药物输送通过希夫基系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.