Association between adverse life events, DNA methylation and risk of premature ovarian insufficiency.

IF 3.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI:10.1080/13697137.2025.2610484

Shuang Yuan, Liutong Wei, Junyan Sun, Yihui Fan, Meiling Li, Lulu Wang, Qiuwan Zhang, Qian Wang, Shengju Yin, Dongmei Lai

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引用次数: 0

Abstract

Objective: This study aimed to assess psychological and lifestyle risk factors for premature ovarian insufficiency (POI) and their association with DNA methylation.

Methods: A case-control study was conducted in Shanghai (2017-2022), including 304 controls and 160 newly diagnosed cases with POI (diagnosed within the past 6 months). Cumulative adverse life events were assessed using the life event scale (LES), and genome-wide DNA methylation was evaluated in whole blood-derived DNA obtained from a sub-sample.

Results: The median total event score for POI patients and control individuals was 48.5 and 20.0, respectively (p < 0.001). Participants experiencing more stressful life events (LES >32) were 2.33-fold more likely to have POI compared to controls (odds ratio 2.33, 95% confidence interval 1.53-3.56). Genome-wide DNA methylation analysis identified 5582 differentially methylated sites (DMSs) between POI patients and controls. Further analysis showed that higher negative life events scores were significantly associated with accelerated DNA methylation aging in the POI group (β = 0.06, p < 0.001).

Conclusion: This case-control study revealed that cumulative stressful or adverse life events were associated with an increased risk of POI, and that accelerated epigenetic aging was correlated with chronic stress in POI patients. These findings suggest potential links that warrant further mechanistic investigation.

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不良生活事件、DNA甲基化与卵巢功能不全风险之间的关系。

目的：本研究旨在评估卵巢早衰（POI）的心理和生活方式危险因素及其与DNA甲基化的关系。方法：在上海市（2017-2022年）开展病例-对照研究，包括304例对照和160例新诊断POI（最近6个月内诊断）。使用生活事件量表（LES）评估累积不良生活事件，并对从亚样本中获得的全血来源DNA进行全基因组DNA甲基化评估。结果：POI患者和对照组的中位总事件评分分别为48.5和20.0 (p 32)，发生POI的可能性是对照组的2.33倍（优势比2.33,95%可信区间1.53-3.56）。全基因组DNA甲基化分析在POI患者和对照组之间鉴定出5582个差异甲基化位点（dms）。进一步分析表明，较高的负性生活事件评分与POI组DNA甲基化老化加速显著相关（β = 0.06, p）。结论：本病例对照研究显示，累积应激或不良生活事件与POI患者POI风险增加相关，加速表观遗传老化与POI患者慢性应激相关。这些发现表明了潜在的联系，需要进一步的机制调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.