Copper-catalyzed annulation of oxime acetates with benzimidates: a new access to substituted pyridines

Abstract

A copper-catalyzed annulation of oxime acetates and benzimidates has been developed via the reductive cleavage of the N–O bond. The reaction proceeds smoothly with a broad range of substrates, giving access to a variety of substituted pyridine derivatives in moderate to good yields. This methodology features the use of inexpensive catalysts and the avoidance of additional ligands and additives.