Precision conversion of colorectal cancer lung metastases: A personalized quadruplet regimen integrating photodynamic therapy with targeted, immunotherapy, and chemotherapy

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2026-04-01 Epub Date: 2026-01-22 DOI:10.1016/j.pdpdt.2026.105362

Qinying Han , Lei Gao , Yunpeng Wang , Zhuanfang Wang , Lijuan He , Ben Liu , Jike Hu , Bo Xu , Hao Chen

引用次数: 0

Abstract

Significance

Colorectal cancer (CRC) has a high incidence and mortality rate, with lung metastasis being the second most common site. Current treatments have limited efficacy, and novel approaches are needed.

Approach

We report a case of a middle-aged female with CRC and lung metastasis treated with four cycles of PDT and five cycles of systemic therapy, including chemotherapy, targeted therapy, and immunotherapy.

Results

After treatment, the lung metastases showed cystic changes, and the primary tumor significantly regressed (TRG: AJCC 0, Becker 1a). The patient successfully underwent surgical treatment.

Conclusions

This multimodal therapy shows promise in CRC lung metastasis, offering new insights for treatment.

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结直肠癌肺转移的精确转化：将光动力治疗与靶向、免疫治疗和化疗相结合的个性化四联体方案。

意义：结直肠癌（Colorectal cancer， CRC）具有较高的发病率和死亡率，肺转移是第二常见的转移部位。目前的治疗方法疗效有限，需要新的治疗方法。方法：我们报告一例中年女性结直肠癌合并肺转移患者，接受4个周期的PDT治疗和5个周期的全身治疗，包括化疗、靶向治疗和免疫治疗。结果：治疗后肺转移灶呈囊性改变，原发肿瘤明显消退（TRG: AJCC 0, Becker 1a）。病人成功地接受了手术治疗。结论：这种多模式治疗在结直肠癌肺转移中有希望，为治疗提供了新的见解。该病例是第一例PDT联合全身治疗的报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.