Advances in sleep research based on the Caenorhabditis elegans: an intestinal microbiota perspective and cutting-edge technology applications

IF 11.6 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI:10.1016/j.smrv.2026.102229

Wan-Qi Zhang , Xiao-Lin Li , Rui-Peng Xu , Yu-Long Li , Peng-Fei Hu , Ka-Hing Wong , Zhong-Yang Lin , Qiong-Qiong Yang , Bo-Bo Zhang

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引用次数: 0

Abstract

Sleep disorders affect approximately 27 % of the global population, driving non-pharmacological research on gut-brain axis regulation. Understanding sleep mechanisms is crucial, given its profound impact on health and disease. Caenorhabditis elegans (C. elegans) offers a powerful model for dissecting fundamental sleep processes, owing to its compact and fully mapped nervous system, genetic tractability, and suitability for high-throughput screening. This review leverages C. elegans integrated with gene editing, high-throughput behavioral phenotyping, and calcium imaging to dissect gut microbiota's role in sleep modulation. We explore how microbial metabolites regulate sleep via gut-brain pathways and summarize conserved sleep-related molecular mechanisms. The purpose of this review is to decode gut-brain-sleep axis interactions, offering novel mechanistic insights into sleep disorder pathophysiology.

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基于秀丽隐杆线虫的睡眠研究进展：肠道微生物群视角和前沿技术应用

睡眠障碍影响了全球约27%的人口，推动了肠-脑轴调节的非药物研究。考虑到睡眠对健康和疾病的深远影响，了解睡眠机制是至关重要的。秀丽隐杆线虫（秀丽隐杆线虫）提供了一个强大的模型，解剖基本的睡眠过程，由于其紧凑和完全映射的神经系统，遗传易感，适合高通量筛选。本综述利用秀丽隐杆线虫整合基因编辑、高通量行为表型和钙成像来解剖肠道微生物群在睡眠调节中的作用。我们探索微生物代谢物如何通过肠-脑通路调节睡眠，并总结保守的睡眠相关分子机制。本综述的目的是解码肠-脑-睡眠轴的相互作用，为睡眠障碍的病理生理学提供新的机制见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine Reviews 医学-临床神经学

CiteScore

20.10

自引率

3.80%

发文量

107

期刊介绍： Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.