Review of fibromyalgia treatment guidelines: part 2 - pharmacological treatment.

IF 2.8 4区医学 Q3 RHEUMATOLOGY

Advances in Rheumatology Pub Date : 2026-01-22 DOI:10.1186/s42358-025-00483-2

Roberto Ezequiel Heymann, Marcelo Cruz Rezende, Eduardo Dos Santos Paiva, Marcos Renato de Assis, Alessandra de Sousa Braz, Aline Ranzolin, Ana Paula Monteiro Gomides Reis, Andrea Pimentel Fonseca Golmia, Anna Beatriz Assad Maia, Denison Santos Silva, Fernando Augusto Chiuchetta, Gabriela Galassi, Izabela Guimarães, José Eduardo Martinez, José Roberto Provenza, Juliana Maria de Freitas Trindade Costa, Marcos Paulo Veloso Correia, Marco Antônio Gonçalves Pontes Filho, Marco Aurelio Goldenfum, Marcos Aurelio de Freitas Machado, Melissa Mariti Fraga, Nilton Salles Rosa Neto, Rafael Navarrete Fernandez

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引用次数: 0

Abstract

Fibromyalgia is a complex condition characterized by widespread chronic pain, fatigue, and sleep disturbances, which significantly affect quality of life. Its pathophysiology involves central sensitization (CS) and changes in neurotransmitters. Management is challenging and requires a multidisciplinary approach that integrates pharmacological and nonpharmacological treatments. This consensus, which is based on the BASCE system, presents updated guidelines for drug and nondrug treatments. The methodology focused on the evaluation of meta-analyses and systematic reviews of the literature and on voting by experts from the Brazilian Society of Rheumatology, ensuring recommendations with at least 70% agreement. Divided into two articles, this article addresses pharmacological strategies, incorporating recent advances to optimize clinical management and promote uniformity in professional practice.

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纤维肌痛治疗指南综述：第2部分-药物治疗。

纤维肌痛是一种以广泛的慢性疼痛、疲劳和睡眠障碍为特征的复杂疾病，严重影响生活质量。其病理生理机制涉及中枢致敏（CS）和神经递质的改变。管理是具有挑战性的，需要多学科的方法，整合药物和非药物治疗。这一共识基于BASCE系统，提出了药物和非药物治疗的最新指南。该方法侧重于对文献的荟萃分析和系统评价以及巴西风湿病学会专家的投票，确保建议至少有70%的一致性。本文分为两篇文章，讨论药理学策略，结合最新进展，以优化临床管理和促进专业实践的统一性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Rheumatology Medicine-Rheumatology

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

53 weeks

期刊介绍： Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.