Antimicrobial activity of native Lactobacillus cell-free supernatant against diarrheagenic Escherichia coli isolated from hospitalized patients in northern Iran

IF 1.5 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI:10.1016/j.ijmmb.2026.101063

Farzaneh Rafie Sedaghat , Ali Mojtahedi , Meysam Hasannejad-Bibalan , Tofigh Yaghubi Kalurazi , Tohid Samadpour Zahmat-dar

{"title":"Antimicrobial activity of native Lactobacillus cell-free supernatant against diarrheagenic Escherichia coli isolated from hospitalized patients in northern Iran","authors":"Farzaneh Rafie Sedaghat , Ali Mojtahedi , Meysam Hasannejad-Bibalan , Tofigh Yaghubi Kalurazi , Tohid Samadpour Zahmat-dar","doi":"10.1016/j.ijmmb.2026.101063","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aims</h3><div>Antibiotic resistance is a growing concern in the fight against <em>Escherichia coli</em>, a pathogen that causes various intestinal diseases. The present study explores the antibacterial effect of <em>lactobacillus</em> on <em>E. coli</em> pathotypes.</div></div><div><h3>Methods</h3><div>Inpatients stool samples were collected and <em>E. coli</em> pathotypes were identified. The antibacterial effect of five <em>Lactobacillus</em> on the pathotypes was investigated by broth microdilution and well diffusion methods.</div></div><div><h3>Results</h3><div>The CFS of <em>L. plantarum, L. rueteri</em> and <em>L. acidophilus</em> had the greatest antibacterial effect.</div></div><div><h3>Conclusion</h3><div>Postbiotics have shown significant bactericidal effects against <em>E. coli</em> pathotypes. Their bactericidal effect can prevent the colonization of these pathotypes in hospitalized patients.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"60 ","pages":"Article 101063"},"PeriodicalIF":1.5000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Medical Microbiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0255085726000216","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/20 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and aims

Antibiotic resistance is a growing concern in the fight against Escherichia coli, a pathogen that causes various intestinal diseases. The present study explores the antibacterial effect of lactobacillus on E. coli pathotypes.

Methods

Inpatients stool samples were collected and E. coli pathotypes were identified. The antibacterial effect of five Lactobacillus on the pathotypes was investigated by broth microdilution and well diffusion methods.

Results

The CFS of L. plantarum, L. rueteri and L. acidophilus had the greatest antibacterial effect.

Conclusion

Postbiotics have shown significant bactericidal effects against E. coli pathotypes. Their bactericidal effect can prevent the colonization of these pathotypes in hospitalized patients.

查看原文本刊更多论文

原生无细胞乳酸杆菌上清液对伊朗北部住院患者分离的致泻性大肠杆菌的抑菌活性

背景和目的：抗生素耐药性是对抗大肠杆菌的一个日益关注的问题，大肠杆菌是一种引起多种肠道疾病的病原体。本研究探讨乳酸菌对大肠杆菌病原菌的抑菌作用。方法：收集住院患者粪便标本，鉴定大肠杆菌病原。采用微量肉汤稀释法和孔扩散法研究了5种乳酸菌对病原菌的抑菌作用。结果：植物乳杆菌、鲁氏乳杆菌和嗜酸乳杆菌的CFS抑菌效果最好。结论：益生后制剂对大肠杆菌病原菌有明显的杀菌作用。它们的杀菌作用可以阻止这些病原菌在住院病人体内的定植。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.