Development of biocompatible cinnamon extract loaded carrageenan/polyvinyl alcohol film: Antimicrobial wound dressing for skin infection control

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2026-02-01 Epub Date: 2026-01-19 DOI:10.1016/j.jics.2026.102429

Mai M. Khalaf , Mohamed Gouda , Manal F. Abou Taleb , Mahmoud A. Abdelaziz , Hany M. Abd El-Lateef

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Abstract

This study aims to evaluate the antimicrobial, antioxidant, and toxicological properties of a biocompatible wound dressing film composed of crude ethanolic cinnamon (CEC) extract- infused carrageenan (CAR)/polyvinyl alcohol (PVA). The CEC showed potent antibacterial activity against Pseudomonas aeruginosa (23 mm inhibition zone) and Acinetobacter baumannii (21 mm). Antioxidant activity results proved the CEC extract's free radical scavenger ability (93 % inhibition). The prepared films demonstrated wider inhibition zones than the CAR/PVA films alone, demonstrating enhanced antimicrobial activity against tested microbes. Furthermore, the inclusion of CEC in CAR/PVA films enhanced the antibacterial activity, achieving a total bacterial log reduction for MRSA and Candida albicans within 150 min. The results of the toxicity assessment confirmed that the films were biocompatible, with EC₅₀_% values exceeding 100. The findings of the study confirmed the promise of CEC loaded CAR/PVA films to be used as efficient biocompatible and non-toxic wound dressings.

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生物相容性肉桂提取物负载卡拉胶/聚乙烯醇薄膜的研制：用于皮肤感染控制的抗菌创面敷料

本研究旨在评价由粗乙醇肉桂（CEC）提取物注入卡拉胶(CAR)/聚乙烯醇（PVA）组成的生物相容性伤口敷料膜的抗菌、抗氧化和毒理学性能。CEC对铜绿假单胞菌（23 mm抑菌区）和鲍曼不动杆菌（21 mm抑菌区）具有较强的抑菌活性。抗氧化活性结果表明，CEC提取物具有清除自由基的能力（抑制93%）。与单独的CAR/PVA膜相比，制备的膜具有更宽的抑制区，显示出对测试微生物的增强抑菌活性。此外，在CAR/PVA膜中加入CEC增强了抗菌活性，在150分钟内实现了MRSA和白色念珠菌的总细菌对数减少。毒性评价结果证实膜具有生物相容性，EC50%值超过100。研究结果证实了CEC负载CAR/PVA薄膜作为高效生物相容性和无毒伤口敷料的前景。

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.