Effects of corrosion rate, mechanical properties, toxicity, and bone healing towards different surface modification of biodegradable metallic: A systematic review

IF 9.4 3区材料科学 Q1 GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY

Materials Today Sustainability Pub Date : 2026-03-01 Epub Date: 2026-01-14 DOI:10.1016/j.mtsust.2026.101307

Siti Adawiyah Zulkefli , Nurin Tihani Nazemi , Zatul Faqihah Mohd Salaha , Gan Hong Seng , Mohammed Rafiq Abdul Kadir , Muhammad Hanif Ramlee

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引用次数: 0

Abstract

Magnesium and its alloys are promising biodegradable implant materials for developing orthopaedic implants. However, the drawback of pure Mg and Mg alloys is their high degradation rate in a biological environment. Thus, several strategies are implemented to enhance corrosion resistance and biocompatibility and achieve a controlled degradation rate for these implants by using surface modification. This systematic review addressed the importance of corrosion rate, mechanical properties, toxicity, and bone healing of the biodegradable metallic implant coated with other materials. From the review, the study indicates that chemical and physical coatings are among the most extensively studied strategies for enhancing the performance of orthopaedic implants. For example, a composite coating made of polycaprolactone (PCL), and amorphous calcium carbonate (ACC) particles has shown improved corrosion resistance when tested in simulated body fluid (SBF). Furthermore, bioactivity osteointegration could be enhanced by calcium phosphate (CaP) coating, such as brushite, β-tricalcium phosphate, and hydroxyapatite. Several studies have shown that a compact HA coating has excellent corrosion resistance and good biocompatibility, which are suitable for biodegradable metal orthopaedic implants. These findings highlight the various successful surface modification methods that could enhance the biodegradable metal implants.

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不同表面改性对生物可降解金属的腐蚀速率、力学性能、毒性和骨愈合的影响：系统综述

镁及其合金是一种很有前途的生物可降解植入材料。然而，纯镁和镁合金的缺点是它们在生物环境中的降解率高。因此，采用几种策略来增强这些植入物的耐腐蚀性和生物相容性，并通过表面改性来实现可控制的降解率。本文系统综述了生物可降解金属种植体的腐蚀速率、机械性能、毒性和骨愈合的重要性。综上所述，研究表明化学和物理涂层是提高骨科植入物性能的最广泛研究的策略之一。例如，在模拟体液（SBF）中测试时，由聚己内酯（PCL）和无定形碳酸钙（ACC）颗粒制成的复合涂层显示出更好的耐腐蚀性。此外，磷酸钙（CaP）涂层（如刷石、β-磷酸三钙和羟基磷灰石）可以增强骨整合的生物活性。多项研究表明，致密的羟基磷灰石涂层具有优异的耐腐蚀性和良好的生物相容性，适用于生物可降解金属骨科植入物。这些发现强调了各种成功的表面改性方法可以增强生物可降解金属植入物。

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来源期刊

Materials Today Sustainability Multiple-

CiteScore

5.80

自引率

6.40%

发文量

174

审稿时长

32 days

期刊介绍： Materials Today Sustainability is a multi-disciplinary journal covering all aspects of sustainability through materials science. With a rapidly increasing population with growing demands, materials science has emerged as a critical discipline toward protecting of the environment and ensuring the long term survival of future generations.