Prognostic value of liver shear wave elastography after transcatheter aortic valve implantation in severe aortic stenosis

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI:10.1016/j.ijcha.2025.101864

Yutaro Sato , Akihiko Sato , Kazuya Sakamoto , Yuuki Muto , Yu Sato , Tetsuro Yokokawa , Takeshi Shimizu , Tomofumi Misaka , Takashi Kaneshiro , Masayoshi Oikawa , Atsushi Kobayashi , Akiomi Yoshihisa , Yasuchika Takeishi

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Abstract

Background

Shear wave elastography (SWE) is a noninvasive ultrasound technique that quantifies liver stiffness. Previous studies have suggested that liver SWE can serve as an indirect marker of hepatic congestion. However, it remains unclear whether liver SWE measured after transcatheter aortic valve implantation (TAVI) is associated with clinical outcomes.

Methods

A total of 127 consecutive patients with severe aortic stenosis who underwent TAVI and had liver SWE measured using abdominal ultrasonography at discharge were enrolled. Liver SWE was obtained from the right hepatic lobe via an intercostal approach. Patients were stratified by the median liver SWE value (1.36 m/s): low-SWE group (< 1.36 m/s; n = 59) and high-SWE group (≥ 1.36 m/s; n = 68). The primary endpoint was a composite of all-cause death and heart failure (HF) rehospitalization.

Results

All 127 patients were followed for 24 months, during which 21 (16.5 %) experienced the primary endpoint. Kaplan–Meier analysis showed a higher cumulative incidence of the primary endpoint in the high-SWE group than in the low-SWE group (log-rank P = 0.019). In Cox proportional hazards models adjusted using inverse probability of treatment weighting, high liver SWE was independently associated with an increased risk of the primary endpoint (hazard ratio 3.66; 95 % confidence interval 1.30–10.32; P = 0.014).

Conclusion

High liver SWE after TAVI was independently associated with an increased 24-month risk of all-cause death and HF rehospitalization.

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经导管主动脉瓣置入术后肝剪切波弹性成像对严重主动脉瓣狭窄患者的预后价值

横波弹性成像（SWE）是一种量化肝脏硬度的无创超声技术。先前的研究表明肝脏SWE可以作为肝充血的间接标志。然而，目前尚不清楚经导管主动脉瓣植入术（TAVI）后肝脏SWE测量是否与临床结果相关。方法选取连续127例重度主动脉瓣狭窄患者，均行TAVI手术，出院时腹部超声测量肝脏SWE。肝SWE通过肋间入路从右肝叶获得。按肝脏SWE中值（1.36 m/s）分为低SWE组（< 1.36 m/s, n = 59）和高SWE组（≥1.36 m/s, n = 68）。主要终点是全因死亡和心力衰竭（HF）再住院。结果127例患者随访24个月，其中21例（16.5%）达到主要终点。Kaplan-Meier分析显示，高swe组的主要终点累积发生率高于低swe组（log-rank P = 0.019）。在使用治疗加权逆概率调整的Cox比例风险模型中，肝脏SWE高与主要终点风险增加独立相关（风险比3.66；95%可信区间1.30-10.32;P = 0.014）。结论TAVI术后高肝SWE与24个月全因死亡和HF再住院风险增加独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.