Association between homocysteine levels and arterial stiffness in the adult population: a systematic review and meta-analysis.

IF 3.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Postgraduate Medical Journal Pub Date : 2026-08-21 DOI:10.1093/postmj/qgaf137

Alicia Saz-Lara, Andrea Del Saz-Lara, Carla Geovanna Lever-Megina, Sara Valladolid-Ayllón, David Tébar-García, Eva María Galán-Moya, Iván Cavero-Redondo

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引用次数: 0

Abstract

Purpose: The aim was to evaluate the association between homocysteine levels and arterial stiffness in the adult population.

Methods: Scopus, Web of Science, and PubMed databases were searched from their inception to November 30, 2024. The DerSimonian and Laird method was used to calculate pooled odds ratio (OR) estimates and 95% confidence intervals (95% CIs) of the associations between homocysteine levels (plasma and serum homocysteine) and arterial stiffness in the adult population.

Results: Finally, 17 studies were included in the systematic review, and 16 studies were included in the meta-analysis, and included a total of 31 049 subjects. Our findings provide evidence supporting the associations between plasma homocysteine levels and arterial stiffness (OR: 2.06; 95% CI: 1.50, 2.82) and between serum homocysteine levels and arterial stiffness (OR: 1.76; 95% CI: 1.17, 2.65) in the adult population.

Conclusion: For each μmol/L unit increase in homocysteine levels, the risk of arterial stiffness increased by 106% for plasma homocysteine and by 76% for serum homocysteine. These findings are of clinical importance for understanding the underlying mechanisms involved in vascular dysfunction to establish preventive strategies in the cardiovascular setting.

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成人同型半胱氨酸水平与动脉僵硬之间的关系：一项系统综述和荟萃分析。

目的：目的是评估成人同型半胱氨酸水平与动脉僵硬之间的关系。方法：检索Scopus、Web of Science和PubMed数据库自建立之日起至2024年11月30日。采用DerSimonian和Laird方法计算成人同型半胱氨酸水平（血浆和血清同型半胱氨酸）与动脉僵硬度之间的合并比值比（OR）和95%置信区间（95% ci）。结果：最终系统评价纳入17项研究，meta分析纳入16项研究，共纳入31 049名受试者。我们的研究结果为成人血浆同型半胱氨酸水平与动脉硬度之间（OR: 2.06; 95% CI: 1.50, 2.82）以及血清同型半胱氨酸水平与动脉硬度之间（OR: 1.76; 95% CI: 1.17, 2.65）的相关性提供了证据。结论：同型半胱氨酸水平每增加1 μmol/L，血浆同型半胱氨酸升高106%，血清同型半胱氨酸升高76%。这些发现对于理解血管功能障碍的潜在机制以建立心血管疾病的预防策略具有重要的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postgraduate Medical Journal 医学-医学：内科

CiteScore

8.50

自引率

2.00%

发文量

131

审稿时长

2.5 months

期刊介绍： Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.