{"title":"Deciphering Usage and Expenditures of Complementary Medicine: A Five-Year Longitudinal Data Analysis of 205,423 Individuals","authors":"David De Ridder DDR, MEng, PhD, Christophe Bagnoud CB, MSc, PhD, Stéphane Joost SJ, MEng, PhD, Idris Guessous IG, MD, PhD","doi":"10.1016/j.mayocp.2025.09.018","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To identify factors associated with complementary and alternative medicine (CAM) use, investigate regional patterns, and examine whether CAM usage is associated with decreased expenditures in conventional medicine (CM).</div></div><div><h3>Participants and Methods</h3><div>We conducted a retrospective analysis of Swiss health insurance claims data from January 1, 2017, to December 31, 2021, including mandatory health insurance (MHI) and supplementary insurance (SI) schemes. We analyzed 816,080 person-years from 205,423 Swiss residents with dual coverage using 2-part multilevel models and geographic clustering analyses.</div></div><div><h3>Results</h3><div>CAM utilization differed markedly between schemes: 59% (481,176 of 816,080) used CAM (SI) while 2.2% (18,023) used CAM (MHI). Women had nearly double the odds of CAM (MHI) usage (adjusted odds ratio, 1.97; <em>P</em><.001) and 56% higher odds of CAM (SI) usage (adjusted odds ratio, 1.56; <em>P</em><.001). Higher socioeconomic status was associated with dose-response relationships, with increased usage across both schemes. Substantial geographic variations emerged, with French-speaking regions having 33% lower odds of CAM (MHI) usage (adjusted odds ratio, 0.67; <em>P</em><.001) yet 26.6% higher expenditures (<em>P</em><.001) among users. CAM users initially incurred 49.1% higher CM expenditures, but this gap narrowed to 34.2% by year 5, representing a 14.9 percentage point convergence. This pattern was most pronounced among individuals without chronic conditions based on medication patterns (CAM MHI: 139.7% to 20.1% difference) and patients with cancer (CAM SI: expenditure differences shifted from +13.9% to −5.9%).</div></div><div><h3>Conclusion</h3><div>CAM serves distinct populations through different insurance schemes, with initial higher CM costs but slower expenditure growth over time. These findings suggest expenditure patterns that warrant further mechanistic investigation to optimize integrative health care delivery.</div></div>","PeriodicalId":18334,"journal":{"name":"Mayo Clinic proceedings","volume":"101 9","pages":"Pages 1529-1557"},"PeriodicalIF":6.5000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mayo Clinic proceedings","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0025619625005531","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/22 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
To identify factors associated with complementary and alternative medicine (CAM) use, investigate regional patterns, and examine whether CAM usage is associated with decreased expenditures in conventional medicine (CM).
Participants and Methods
We conducted a retrospective analysis of Swiss health insurance claims data from January 1, 2017, to December 31, 2021, including mandatory health insurance (MHI) and supplementary insurance (SI) schemes. We analyzed 816,080 person-years from 205,423 Swiss residents with dual coverage using 2-part multilevel models and geographic clustering analyses.
Results
CAM utilization differed markedly between schemes: 59% (481,176 of 816,080) used CAM (SI) while 2.2% (18,023) used CAM (MHI). Women had nearly double the odds of CAM (MHI) usage (adjusted odds ratio, 1.97; P<.001) and 56% higher odds of CAM (SI) usage (adjusted odds ratio, 1.56; P<.001). Higher socioeconomic status was associated with dose-response relationships, with increased usage across both schemes. Substantial geographic variations emerged, with French-speaking regions having 33% lower odds of CAM (MHI) usage (adjusted odds ratio, 0.67; P<.001) yet 26.6% higher expenditures (P<.001) among users. CAM users initially incurred 49.1% higher CM expenditures, but this gap narrowed to 34.2% by year 5, representing a 14.9 percentage point convergence. This pattern was most pronounced among individuals without chronic conditions based on medication patterns (CAM MHI: 139.7% to 20.1% difference) and patients with cancer (CAM SI: expenditure differences shifted from +13.9% to −5.9%).
Conclusion
CAM serves distinct populations through different insurance schemes, with initial higher CM costs but slower expenditure growth over time. These findings suggest expenditure patterns that warrant further mechanistic investigation to optimize integrative health care delivery.
期刊介绍:
Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.