MMP9 Genetic Variants in Schizophrenia Spectrum Disorders and Its Relation with Cognitive Dysfunction and Suicide Attempt.

IF 1.8 Q3 PSYCHIATRY

Indian Journal of Psychological Medicine Pub Date : 2026-01-18 DOI:10.1177/02537176251409364

Neha Keshri, Hanumanthappa Nandeesha, Vikas Menon, Medha Rajappa

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引用次数: 0

Abstract

Background: The present study was designed to investigate the MMP9 genetic variants (rs20544 and rs17576) and plasma MMP9 in patients with schizophrenia spectrum disorders and their relation with cognition and suicide attempt.

Methods: The study comprises 216 patients with schizophrenia spectrum disorders and 216 age-matched controls. MMP-9 genetic variants were genotyped using a TaqMan Allelic Discrimination assay in schizophrenia and controls. Addenbrooke's Cognitive Examination III (ACE-III) scores were used to evaluate cognitive status. Suicidal ideation was assessed using the Columbia suicide severity rating (CSSR) scores. The genetic data were analyzed using the χ ² test, and plasma MMP-9 levels were compared across schizophrenia genotypes using the Kruskal-Wallis test.

Results: The GG variant (OR: 1.99, 95% CI: 1.182-3.38, p = .007), AG variant (OR: 1.76, 95% CI: 1.101-2.823, p = .01) and G allele (OR: 1.45, 95% CI: 1.11-1.90, p = .004) of rs17576 showed higher frequency in patients with schizophrenia in comparison with controls. The CC genotype variant (OR: 0.4916, 95% CI: 0.2723-0.8874, p = .01) and the C allele (OR: 0.776, 95% CI: 0.580-1.021, p = .04) of rs20544 showed lower frequencies in patients with schizophrenia compared with controls. Plasma MMP9 levels were higher in TT (p = .01) and CT genotypes (p = .01) in comparison with the CC genotype of rs20544 in schizophrenia. Plasma MMP-9 levels were not significantly different among genotypes of the rs17576 variant.

Conclusion: We conclude that the MMP9 genetic variants were associated with schizophrenia spectrum disorders, but not with cognitive impairment and suicide attempt.

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精神分裂症谱系障碍的MMP9基因变异及其与认知功能障碍和自杀企图的关系

背景：本研究旨在探讨精神分裂症谱系障碍患者MMP9基因变异（rs20544和rs17576）和血浆MMP9与认知和自杀企图的关系。方法：研究对象为216例精神分裂症谱系障碍患者和216例年龄匹配的对照组。使用TaqMan等位基因辨别法对精神分裂症和对照组的MMP-9遗传变异进行基因分型。采用阿登布鲁克认知检查III （ACE-III）评分评估认知状态。采用哥伦比亚自杀严重程度评分（CSSR）对自杀意念进行评估。采用χ 2检验分析遗传数据，并采用Kruskal-Wallis检验比较不同精神分裂症基因型的血浆MMP-9水平。结果：rs17576的GG变异（OR: 1.99, 95% CI: 1.182 ~ 3.38, p = 0.007）、AG变异（OR: 1.76, 95% CI: 1.101 ~ 2.823, p = 0.01）和G等位基因（OR: 1.45, 95% CI: 1.11 ~ 1.90, p = 0.004）在精神分裂症患者中出现的频率高于对照组。与对照组相比，rs20544的CC基因型变异（OR: 0.4916, 95% CI: 0.2723-0.8874, p = 0.01）和C等位基因（OR: 0.776, 95% CI: 0.580-1.021, p = 0.04）在精神分裂症患者中的出现频率较低。与rs20544基因型CC患者相比，TT基因型和CT基因型患者血浆MMP9水平均较高（p = 0.01）。不同rs17576变异基因型的血浆MMP-9水平无显著差异。结论：我们得出结论，MMP9基因变异与精神分裂症谱系障碍有关，但与认知障碍和自杀企图无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Psychological Medicine PSYCHOLOGY-

CiteScore

4.80

自引率

7.10%

发文量

116

审稿时长

12 weeks

期刊介绍： The Indian Journal of Psychological Medicine (ISSN 0253-7176) was started in 1978 as the official publication of the Indian Psychiatric Society South Zonal Branch. The journal allows free access (Open Access) and is published Bimonthly. The Journal includes but is not limited to review articles, original research, opinions, and letters. The Editor and publisher accept no legal responsibility for any opinions, omissions or errors by the authors, nor do they approve of any product advertised within the journal.