Bacterial-derived γ-aminobutyric acid (GABA) regulates larval settlement and metamorphosis of Mytilus coruscus.

IF 2.5 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biofouling Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI:10.1080/08927014.2025.2603451

Xiuping Yang, Xiaoyu Wang, Lihua Peng, Sergey Dobretsov, Jin-Long Yang, Xiao Liang

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Abstract

Bacteria play a vital role in the settlement and metamorphosis of marine invertebrates. However, the molecular mechanisms by which bacteria regulate the metamorphosis from larva to juvenile remain unknown. This study aims to investigate whether bacteria derived from Mytilus coruscus affect the larval settlement and metamorphosis of this species. Our results showed that all eight bacterial strains can induce settlement and metamorphosis in this mussel species. Polysaccharides and gamma-aminobutyric acid (GABA) produced by bacteria positively trigger this transformation in mussels, with GABA acting as the primary inducer. Marinomonas foliarum exhibited the highest GABA production and induction activity among the experimental strains. Compared with biofilms alone, the addition of a GABA synthesis inhibitor during Marinomonas foliarum biofilm formation reduced its induction activity by 56.02%. Our results reveal a novel role of bacterial GABA in triggering mussel larval settlement and metamorphosis.

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细菌源γ-氨基丁酸（GABA）调控贻贝幼体沉降和变态。

细菌在海洋无脊椎动物的定居和蜕变中起着至关重要的作用。然而，细菌调控幼虫向幼鱼蜕变的分子机制尚不清楚。本研究旨在探讨来自贻贝（Mytilus coruscus）的细菌是否会影响该物种的幼虫定居和变态。结果表明，8种菌株均能诱导该贻贝的沉降和变形。细菌产生的多糖和γ -氨基丁酸（GABA）积极触发贻贝的这种转化，其中GABA是主要的诱导性物质。叶片Marinomonas foliarum表现出最高的GABA产量和诱导活性。与单独形成生物膜相比，在叶状Marinomonas foliarum生物膜形成过程中添加GABA合成抑制剂使其诱导活性降低了56.02%。我们的研究结果揭示了细菌GABA在触发贻贝幼虫定居和变态中的新作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biofouling 生物-海洋与淡水生物学

CiteScore

5.00

自引率

7.40%

发文量

审稿时长

1.7 months

期刊介绍： Biofouling is an international, peer-reviewed, multi-discliplinary journal which publishes original articles and mini-reviews and provides a forum for publication of pure and applied work on protein, microbial, fungal, plant and animal fouling and its control, as well as studies of all kinds on biofilms and bioadhesion. Papers may be based on studies relating to characterisation, attachment, growth and control on any natural (living) or man-made surface in the freshwater, marine or aerial environments, including fouling, biofilms and bioadhesion in the medical, dental, and industrial context. Specific areas of interest include antifouling technologies and coatings including transmission of invasive species, antimicrobial agents, biological interfaces, biomaterials, microbiologically influenced corrosion, membrane biofouling, food industry biofilms, biofilm based diseases and indwelling biomedical devices as substrata for fouling and biofilm growth, including papers based on clinically-relevant work using models that mimic the realistic environment in which they are intended to be used.