Precursor B-Cell Acute Lymphoblastic Leukemia With PICALM∶∶MLLT10 Fusion Gene Positivity:Report of One Case and Literature Review.

Q4 Medicine

中国医学科学院学报 Pub Date : 2026-02-01 DOI:10.3881/j.issn.1000-503X.16685

Jie-Jun Zhao, Qian-Min Zeng, Li-Na Wang, Ming Li, Ya-Ming Xi

引用次数: 0

Abstract

PICALM∶∶MLLT10 fusion gene-positive precursor B-cell acute lymphoblastic leukemia(pro-B-ALL)is clinically rare.This article reports the case of a 29-year-old female patient who presented a mediastinal mass.Diagnostic investigations confirmed PICALM∶∶MLLT10 fusion gene-positive pro-B-ALL.The patient sequentially received radiotherapy and multiple lines of chemotherapy but developed short-term drug resistance and lineage change,progressing to mixed-phenotype acute leukemia.A review of relevant literature was conducted to analyze its pathogenesis and molecular characteristics,aiming to provide references for clinical diagnosis and treatment.

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PICALM∶∶MLLT10融合基因阳性前体b细胞急性淋巴细胞白血病1例报告并文献复习

PICALM∶∶MLLT10融合基因阳性的前体b细胞急性淋巴细胞白血病（pro-B-ALL）临床罕见。本文报告一例29岁女性患者，其表现为纵隔肿块。诊断证实PICALM∶∶MLLT10融合基因阳性。患者先后接受放疗和多线化疗，但出现短期耐药和谱系改变，进展为混合表型急性白血病。复习相关文献，分析其发病机制及分子特征，为临床诊治提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].