Pre-transplant hemodynamic profiles of patients with ischemic vs. non-ischemic cardiomyopathy: insights from a retrospective single-center study.

Abstract

Objectives: Heart transplantation remains the last resort for patients with end-stage heart failure. The clinical and hemodynamic profiles of these patients may differ depending on the underlying etiology of cardiomyopathy. This study aimed to evaluate pre-transplant hemodynamic characteristics in patients with ischemic versus non-ischemic cardiomyopathy.

Methods: We conducted a retrospective analysis of 170 adult patients who underwent orthotopic heart transplantation at a single center. Patients were categorized based on the etiology of heart failure as either ischemic or non-ischemic cardiomyopathy. Preoperative hemodynamic and echocardiographic parameters were compared between the groups.

Results: Of the 170 patients, 45.2% had ischemic cardiomyopathy. These patients were significantly older than those with non-ischemic cardiomyopathy (53.2 vs. 46.7 years, P<0.01). However, no significant differences were observed between the two groups in pulmonary capillary wedge pressure (17.9 ± 8.0 vs. 17.4 ± 9.5 mmHg), mean pulmonary artery pressure (29.4 ± 10.9 vs. 27.3 ± 12.6 mmHg), or left ventricular ejection fraction (21.4 ± 10.8% vs. 23.3 ± 12.5%).

Conclusion: While ischemic cardiomyopathy patients were older, their preoperative hemodynamic and echocardiographic profiles were closely similar to those with non-ischemic cardiomyopathy.