A stretchable continuous glucose monitor for skin-conformable wound management

IF 11.8 1区生物学 Q1 BIOPHYSICS

Biosensors and Bioelectronics Pub Date : 2026-04-15 Epub Date: 2025-12-27 DOI:10.1016/j.bios.2025.118345

Binbin Cui , Ivo Pang , Shilei Dai, Xiaonan Chen, Dingyao Liu, Xinyu Tian, Wensheng Lin, Jing Bai, Xinran Zhang, Shiming Zhang

{"title":"A stretchable continuous glucose monitor for skin-conformable wound management","authors":"Binbin Cui , Ivo Pang , Shilei Dai, Xiaonan Chen, Dingyao Liu, Xinyu Tian, Wensheng Lin, Jing Bai, Xinran Zhang, Shiming Zhang","doi":"10.1016/j.bios.2025.118345","DOIUrl":null,"url":null,"abstract":"<div><div>Chronic wounds, especially those linked to diabetes, require continuous monitoring and timely interventions to prevent severe complications. The emergence of smart bandages equipped with multifunctional sensors offers a promising avenue to alleviate the burden on healthcare systems while minimizing delays in medical care. However, conventional electrochemical sensors often face limitations, including inadequate detection sensitivity and poor mechanical compatibility with biological tissue, thereby restricting their utility in smart bandages for long-term wound care applications. In this study, we present a stretchable continuous glucose monitor (CGM), based on organic electrochemical transistors (OECTs), for chronic wound care. By leveraging the amplification capability and the mechanical properties of stretchable OECTs, this platform achieves both high sensitivity and tissue compatibility. To demonstrate the potential for practical use, the sensors are integrated into a compact, coin-sized wearable readout system, enabling continuous and comfortable wound monitoring.</div></div>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"298 ","pages":"Article 118345"},"PeriodicalIF":11.8000,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosensors and Bioelectronics","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0956566325012229","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}

引用次数: 0

Abstract

Chronic wounds, especially those linked to diabetes, require continuous monitoring and timely interventions to prevent severe complications. The emergence of smart bandages equipped with multifunctional sensors offers a promising avenue to alleviate the burden on healthcare systems while minimizing delays in medical care. However, conventional electrochemical sensors often face limitations, including inadequate detection sensitivity and poor mechanical compatibility with biological tissue, thereby restricting their utility in smart bandages for long-term wound care applications. In this study, we present a stretchable continuous glucose monitor (CGM), based on organic electrochemical transistors (OECTs), for chronic wound care. By leveraging the amplification capability and the mechanical properties of stretchable OECTs, this platform achieves both high sensitivity and tissue compatibility. To demonstrate the potential for practical use, the sensors are integrated into a compact, coin-sized wearable readout system, enabling continuous and comfortable wound monitoring.

查看原文本刊更多论文

一种适用于皮肤创面管理的可拉伸连续血糖监测仪。

慢性伤口，特别是与糖尿病有关的伤口，需要持续监测和及时干预，以防止严重并发症。配备多功能传感器的智能绷带的出现为减轻医疗保健系统的负担，同时最大限度地减少医疗延误提供了一条有希望的途径。然而，传统的电化学传感器往往面临局限性，包括检测灵敏度不足和与生物组织的机械相容性差，从而限制了它们在智能绷带中长期伤口护理应用中的应用。在这项研究中，我们提出了一种基于有机电化学晶体管（OECTs）的可拉伸连续血糖监测仪（CGM），用于慢性伤口护理。通过利用可拉伸oect的放大能力和机械性能，该平台实现了高灵敏度和组织相容性。为了展示实际应用的潜力，传感器被集成到一个紧凑的，硬币大小的可穿戴读出系统中，实现连续和舒适的伤口监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biosensors and Bioelectronics 工程技术-电化学

CiteScore

20.80

自引率

7.10%

发文量

1006

审稿时长

29 days

期刊介绍： Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.