Impact of Lupus on All-Cause, Cardiovascular, and Infection-Related Mortality Among Dialysis Patients: Okinawa Dialysis Study Registry.

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2026-06-01 Epub Date: 2026-01-19 DOI:10.1002/1744-9987.70117

Nanako Oshiro, Yukiko Hasuike, Kentaro Kohagura, Kunitoshi Iseki

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Abstract

Introduction: Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE) and can lead to end-stage kidney disease (ESKD). We aimed to assess the relative mortality risk associated with SLE among dialysis patients.

Methods: This retrospective longitudinal cohort study included all dialysis patients in the Okinawa Dialysis Study 30 registry. Cox proportional hazard models were performed to assess mortality.

Results: Of 5246 patients, 111 had ESKD secondary to SLE. Compared with ESKD patients secondary to other causes, those with SLE had significantly higher risk of death (HR 2.55, 95% CI 1.81-3.47, p < 0.0001), cardiovascular death (HR 1.94, 95% CI 1.13-3.33, p = 0.0158), and infection death (HR 4.21, 95% CI 2.40-7.37, p < 0.0001) after adjusting for age, era of dialysis initiation, and sex.

Conclusion: SLE may be independently associated with an increased risk of death in dialysis patients.

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红斑狼疮对透析患者全因死亡率、心血管死亡率和感染相关死亡率的影响：冲绳透析研究登记处。

狼疮肾炎是系统性红斑狼疮（SLE）最严重的并发症之一，可导致终末期肾脏疾病（ESKD）。我们的目的是评估透析患者SLE相关的相对死亡风险。方法：这项回顾性纵向队列研究包括冲绳透析研究30登记的所有透析患者。采用Cox比例风险模型评估死亡率。结果：5246例患者中，111例为SLE继发ESKD。与继发于其他原因的ESKD患者相比，SLE患者的死亡风险明显更高（HR 2.55, 95% CI 1.81-3.47, p）。结论：SLE可能与透析患者死亡风险增加独立相关。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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