Updating the frequency of CCR5Δ32 in Brazil: Descriptive analysis of malaria cases and controls from Acre State, Amazon region.

IF 1.7 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genetics and Molecular Biology Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI:10.1590/1678-4685-GMB-2025-0056

Marina Ziliotto, Joel Henrique Ellwanger, Jamille Gregório Dombrowski, Claudio Romero Farias Marinho, Alessandra Pontillo, José Artur Bogo Chies

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Abstract

This study updates data on the distribution of CCR5Δ32 allele frequency in populations from Brazilian states. CCR5Δ32 is a variant allele of the CCR5 gene, which prevents (in homozygosity) or reduces (in heterozygosity) the expression of the CCR5 protein on the surface of leukocytes, being an important factor in infectious diseases. Also, this study reports the frequency of CCR5Δ32 in women from the state of Acre, located in the Brazilian Amazon, a region where the Δ32 allele and malaria are observed concurrently. We found allele frequencies of 2.88% in Plasmodium-infected women and of 1.04% among uninfected women. The low Δ32 allele frequencies observed in Acre, compared to other Brazilian regions, could be a reflection of the particular ancestry patterns in current Amazonian populations influenced by past European colonization.

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更新巴西CCR5Δ32的频率：亚马逊地区阿克里州疟疾病例和控制的描述性分析。

这项研究更新了巴西各州人群中CCR5Δ32等位基因频率分布的数据。CCR5Δ32是CCR5基因的一个变异等位基因，它阻止（纯合性）或减少（杂合性）CCR5蛋白在白细胞表面的表达，是传染病的重要因素。此外，本研究报告了位于巴西亚马逊地区的阿克里州妇女中CCR5Δ32的频率，该地区同时观察到Δ32等位基因和疟疾。我们发现，在感染了疟原虫的妇女中，等位基因频率为2.88%，而在未感染的妇女中，等位基因频率为1.04%。与巴西其他地区相比，在阿卡观察到的Δ32等位基因频率较低，这可能反映了受过去欧洲殖民影响的当前亚马逊人口的特定祖先模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics and Molecular Biology 生物-生化与分子生物学

CiteScore

4.20

自引率

4.80%

发文量

111

审稿时长

3 months

期刊介绍： Genetics and Molecular Biology (formerly named Revista Brasileira de Genética/Brazilian Journal of Genetics - ISSN 0100-8455) is published by the Sociedade Brasileira de Genética (Brazilian Society of Genetics). The Journal considers contributions that present the results of original research in genetics, evolution and related scientific disciplines. Manuscripts presenting methods and applications only, without an analysis of genetic data, will not be considered.