Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332.

IF 5.6 2区医学 Q1 TOXICOLOGY

Critical Reviews in Toxicology Pub Date : 2025-01-01 Epub Date: 2026-01-19 DOI:10.1080/10408444.2025.2601199

C Roland Wolf, Colin J Henderson, Michael Schwarz, Francesco Inesta-Vaquera, Richard R Meehan

引用次数: 0

关于评论文章的致编辑信：Yamada T， Cohen SM, Lake BG。一项最新的关键评估表明，组成型雄甾烷受体（CAR）和过氧化物酶体增殖物激活受体α (PPARα)的激活剂对啮齿动物肝脏肿瘤形成的作用模式与人类癌症风险无关。中国生物医学工程学报，2015;55(5):549-586。doi: 10.1080 / 10408444.2025.2513332。

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来源期刊

Critical Reviews in Toxicology 医学-毒理学

CiteScore

9.50

自引率

1.70%

发文量

期刊介绍： Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.