Catalyst free, three components synthesis of new 2-(1,3-dithiol-2-ylidene)malononitrile and 2-(thiazol-2-ylidene)malononitrile from nitroepoxides and malononitrile-heterocumulene adducts

IF 1.7 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Sulfur Chemistry Pub Date : 2026-01-02 Epub Date: 2025-10-24 DOI:10.1080/17415993.2025.2577150

Manijeh Nematpour

引用次数: 0

Abstract

In this study, a one-pot, catalyst-free, and three-component reaction was developed to synthesize various novel 2-(1,3-dithiol-2-ylidene)malononitrile and 2-(thiazol-2-ylidene)malononitrile derivatives at room temperature in good yields. The reaction was carried out via the formation of malononitrile-heterocumulene (carbon disulfide or isothiocyanate) adducts, followed by the addition of nitroepoxide as an efficient starting material to synthesize the products with easy purification. In this process, 15 new heterocyclic compounds from the 1,3-dithiole and thiazole family were synthesized and identified by NMR, Mass, and IR analyses.

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无催化剂，三组分合成新的2-（1,3-二硫醇-2-乙基）丙二腈和2-（噻唑-2-乙基）丙二腈

在本研究中，建立了一锅、无催化剂、三组分的反应，在室温下合成了多种新型的2-（1,3-二硫醇-2-基二烯）丙二腈和2-（噻唑-2-基二烯）丙二腈衍生物，收率较高。该反应是通过生成丙二腈-异硫脲（二硫化碳或异硫氰酸酯）加合物，然后加入硝基环氧化物作为高效的起始原料，合成了易于纯化的产品。在此过程中，共合成了15个新的1,3-二噻唑和噻唑类杂环化合物，并通过NMR、Mass和IR分析对其进行了鉴定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Sulfur Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.10

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science. Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.