Exposing Drosophila to wheat-derived microbes enhances its immunity and survival under simulated microgravity

IF 3.3 3区生物学 Q2 ASTRONOMY & ASTROPHYSICS

Life Sciences in Space Research Pub Date : 2026-01-01 Epub Date: 2025-09-10 DOI:10.1016/j.lssr.2025.09.003

Letian Chen , Shijing Wang , Chuanmeng Cai , Jingjing Cui , Hong Liu , Yuming Fu

{"title":"Exposing Drosophila to wheat-derived microbes enhances its immunity and survival under simulated microgravity","authors":"Letian Chen , Shijing Wang , Chuanmeng Cai , Jingjing Cui , Hong Liu , Yuming Fu","doi":"10.1016/j.lssr.2025.09.003","DOIUrl":null,"url":null,"abstract":"<div><div>During prolonged space habitation, microgravity compromises astronaut immunity, increasing the risk of infectious diseases. Plant-derived microbes offer a promising strategy for enhancing immunity, yet their feasibility and mechanisms remain unclear. We co-cultivated wheat and <em>Drosophila</em> under simulated microgravity (SMG), examining changes in <em>Drosophila</em> immunity through a multi-omics approach. Our findings demonstrate that exposure to wheat-derived microbes significantly boosts <em>Drosophila</em>'s survival and immunity, confirming their transfer and colonization in the host. Notably, immune-related microbes like <em>Massilia</em> and <em>Longimicrobium</em> were enriched. This exposure markedly upregulated <em>Drosophila</em> key immune genes in Toll signaling and glutathione metabolism, enhancing immune substance secretion. Multi-omics cojoint analysis further indicated that these microbes ameliorated immune dysfunction in <em>Drosophila</em>, providing an innovative strategy to bolster astronaut immunity during space missions and a theoretical foundation for life support systems in extended space exploration.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 88-98"},"PeriodicalIF":3.3000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life Sciences in Space Research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214552425001026","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ASTRONOMY & ASTROPHYSICS","Score":null,"Total":0}

引用次数: 0

Abstract

During prolonged space habitation, microgravity compromises astronaut immunity, increasing the risk of infectious diseases. Plant-derived microbes offer a promising strategy for enhancing immunity, yet their feasibility and mechanisms remain unclear. We co-cultivated wheat and Drosophila under simulated microgravity (SMG), examining changes in Drosophila immunity through a multi-omics approach. Our findings demonstrate that exposure to wheat-derived microbes significantly boosts Drosophila's survival and immunity, confirming their transfer and colonization in the host. Notably, immune-related microbes like Massilia and Longimicrobium were enriched. This exposure markedly upregulated Drosophila key immune genes in Toll signaling and glutathione metabolism, enhancing immune substance secretion. Multi-omics cojoint analysis further indicated that these microbes ameliorated immune dysfunction in Drosophila, providing an innovative strategy to bolster astronaut immunity during space missions and a theoretical foundation for life support systems in extended space exploration.

查看原文本刊更多论文

将果蝇暴露于小麦来源的微生物中可以增强其在模拟微重力下的免疫力和存活率

在长时间的太空居住期间，微重力会损害宇航员的免疫力，增加患传染病的风险。植物源性微生物为增强免疫力提供了一种很有希望的策略，但其可行性和机制尚不清楚。我们在模拟微重力（SMG）下共同栽培小麦和果蝇，通过多组学方法研究果蝇免疫的变化。我们的研究结果表明，暴露于小麦来源的微生物显著提高果蝇的存活率和免疫力，证实了它们在宿主中的转移和定植。值得注意的是，免疫相关微生物如马氏菌和Longimicrobium被富集。这种暴露显著上调果蝇Toll信号和谷胱甘肽代谢中的关键免疫基因，增强免疫物质分泌。多组学联合分析进一步表明，这些微生物改善了果蝇的免疫功能障碍，为增强宇航员在太空任务中的免疫力提供了一种创新策略，并为扩展空间探索中的生命支持系统提供了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Life Sciences in Space Research Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

5.30

自引率

8.00%

发文量

期刊介绍： Life Sciences in Space Research publishes high quality original research and review articles in areas previously covered by the Life Sciences section of COSPAR''s other society journal Advances in Space Research. Life Sciences in Space Research features an editorial team of top scientists in the space radiation field and guarantees a fast turnaround time from submission to editorial decision.