Tetracycline toxicity in fish: Recent insights into physiological and health implications

IF 4.6 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology Pub Date : 2026-03-01 Epub Date: 2026-01-15 DOI:10.1016/j.aquatox.2026.107716

Dip Mukherjee , Purandar Sarkar , Surajit Ghosh , Ahamadul Hoque Mandal , Sutapa Sanyal , Saurabh Chakraborti , Nimai Chandra Saha , Paolo Pastorino , Shubhajit Saha

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引用次数: 0

Abstract

Tetracyclines (TCs), a class of broad-spectrum antibiotics widely used in aquaculture, pose significant risks to fish health because of their environmental persistence and tendency to bioaccumulate in aquatic systems. This review synthesizes the toxic effects of TCs across key fish species (e.g., Danio rerio, Cyprinus carpio). TCs compromises respiratory efficiency via gill lamellar fusion, induces intestinal atrophy and inflammation, and alters hematological profiles, impairing oxygen transport and immune function. Biochemically, it disrupts antioxidant defenses, leading to pervasive oxidative stress. At the molecular level, TCs induces genotoxicity. Early life stages exhibit developmental toxicity (e.g., spinal deformities). Immunologically, TCs suppresses phagocytic activity and cytokine release, heightening infection susceptibility. Furthermore, it interferes with bone mineralization and causes muscle degeneration. Overall, TCs contamination represents a substantial threat to fish health and aquatic food webs, necessitating stricter regulations and improved removal strategies.

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四环素对鱼类的毒性：对生理和健康影响的最新见解

四环素（TCs）是一类广泛应用于水产养殖的广谱抗生素，由于其环境持久性和在水生系统中的生物积累倾向，对鱼类健康构成重大风险。本综述综合了TCs对主要鱼类（如达尼罗鱼、鲤鱼）的毒性作用。TCs通过鳃板融合降低呼吸效率，诱导肠道萎缩和炎症，改变血液学特征，损害氧气运输和免疫功能。从生物化学角度来看，它会破坏抗氧化防御，导致普遍的氧化应激。在分子水平上，TCs诱导遗传毒性。生命早期表现出发育毒性（如脊柱畸形）。免疫上，TCs抑制吞噬活性和细胞因子释放，增加感染易感性。此外，它会干扰骨矿化并导致肌肉退化。总体而言，TCs污染对鱼类健康和水生食物网构成重大威胁，需要更严格的法规和改进的清除策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aquatic Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

4.40%

发文量

250

审稿时长

56 days

期刊介绍： Aquatic Toxicology publishes significant contributions that increase the understanding of the impact of harmful substances (including natural and synthetic chemicals) on aquatic organisms and ecosystems. Aquatic Toxicology considers both laboratory and field studies with a focus on marine/ freshwater environments. We strive to attract high quality original scientific papers, critical reviews and expert opinion papers in the following areas: Effects of harmful substances on molecular, cellular, sub-organismal, organismal, population, community, and ecosystem level; Toxic Mechanisms; Genetic disturbances, transgenerational effects, behavioral and adaptive responses; Impacts of harmful substances on structure, function of and services provided by aquatic ecosystems; Mixture toxicity assessment; Statistical approaches to predict exposure to and hazards of contaminants The journal also considers manuscripts in other areas, such as the development of innovative concepts, approaches, and methodologies, which promote the wider application of toxicological datasets to the protection of aquatic environments and inform ecological risk assessments and decision making by relevant authorities.