In vivo quantitative assessments with [11C]T-278, a PET imaging agent for diacylglycerol kinase gamma, in nonhuman primate brain

IF 5.3 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2026-02-15 Epub Date: 2026-01-15 DOI:10.1016/j.neuroimage.2026.121731

Yasushi Hattori , Tomoteru Yamasaki , Yuji Nagai , Takashi Okauchi , Masayuki Fujinaga , Wakana Mori , Takafumi Minamimoto , Makoto Higuchi , Tatsuki Koike , Ming-Rong Zhang

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引用次数: 0

Abstract

Diacylglycerol kinase (DGK) is an enzyme catalyzing ATP-dependent conversion of diacylglycerol to phosphatidic acid. Among DGK subtypes, DGKγ is localized in the brain and plays important roles in the central nervous system, although its detailed functions remain unknown. Recently, [¹¹C]T-278 was developed as a selective positron emission tomography (PET) imaging agent for DGKγ. This study aimed to conduct the first quantitative analysis using PET with [¹¹C]T-278 in nonhuman primate brains. In rhesus monkeys, compartmental analyses showed superior goodness-of-fit in two-tissue compartment model than one-tissue compartment model. Full kinetic analysis of [¹¹C]T-278 yielded reliable estimates of the total distribution volume (V_T) values across various brain regions, showing a strong correlation (slope = 1.07, r > 0.995) with V_T value derived from Logan GA. Furthermore, time-stability analysis for V_T estimations showed small variations (< 5 %) between 70 and 90 min of scan durations across most regions of interest. This study provides the first in vivo visualization of DGKγ in monkey brain using quantitative PET analysis with [¹¹C]T-278.

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[11C]T-278 PET显像剂对二酰基甘油激酶γ的体内定量评价。

二酰基甘油激酶（DGK）是一种酶，催化atp依赖的二酰基甘油转化为磷脂酸。在DGK亚型中，DGKγ定位于大脑并在中枢神经系统中发挥重要作用，尽管其详细功能尚不清楚。最近，[11C]T-278被开发为DGKγ的选择性正电子发射断层扫描（PET）显像剂。本研究旨在首次利用PET对非人灵长类动物大脑中的[11C]T-278进行定量分析。在恒河猴中，区隔分析显示，两组织区隔模型的拟合优度优于一组织区隔模型。对[11C]T-278的全动力学分析得出了脑各区域的总分布体积（VT）值的可靠估计，显示出与Logan GA得出的VT值有很强的相关性（斜率 = 1.07,r > 0.995）。此外，VT估计的时间稳定性分析显示，在大多数感兴趣的区域，扫描持续时间在70到90分钟之间的变化很小（< 5%）。本研究首次利用[11C]T-278进行定量PET分析，实现了DGKγ在猴子大脑中的活体可视化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.