Gentianellin A, an unusual immunosuppressive sesterterpenoid from the traditional Tibetan medicine Gentianella azurea

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI:10.1016/j.tetlet.2026.155972

Xiao-Yu Qi , Yu-Zhou Fan , An-Yu Li , Xue-Fei Li , Jia-Mei Tang , Yuan-Liang Xu , Yan Liu , Xue-Mei Niu , Kai Guo , Sheng-Hong Li

引用次数: 0

Abstract

Gentianellin A (1), a new gentianellane-type sesterterpenoid possessing a 5/7/5/6/5 pentacyclic ring system formed by a bridged ether bond, was isolated from the traditional Tibetan medicine Gentianella azurea. Its structure was elucidated by extensive spectroscopic analysis, single-crystal X-ray diffraction, and quantum chemical calculations. Compound 1 exhibited immunosuppressive activity by inhibiting the secretion of IL-6 and TNF-α in LPS-induced macrophages RAW264.7 with IC₅₀ values of 13.80 and 18.46 μM.

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龙胆草素A是一种罕见的免疫抑制酯萜类化合物，来自传统藏药蓝色龙胆草

龙胆ellin A(1)是从藏药蓝色龙胆中分离得到的具有5/7/5/6/5五环体系的新型龙胆ellane型酯萜类化合物。它的结构通过广泛的光谱分析、单晶x射线衍射和量子化学计算得以阐明。化合物1通过抑制lps诱导的巨噬细胞RAW264.7中IL-6和TNF-α的分泌，显示出免疫抑制活性，IC50值分别为13.80和18.46 μM。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.