Major Depressive Disorder in Youth and Adults: A Quantitative Whole-Brain Meta-Analysis of Functional Magnetic Resonance Imaging Studies

IF 4.9 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-01-13 DOI:10.1016/j.bpsc.2026.01.001

Caitlin Baten , Gladys Zamora , Amanda M. Klassen , Justin Rackley , Akua F. Nimarko , Ellen Woo , Arielle S. Keller , J. Paul Hamilton , Dawson W. Hedges , Matthew D. Sacchet , Ian H. Gotlib , Chris H. Miller

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引用次数: 0

Abstract

Background

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder with limited treatment success in both youth and adults. Functional magnetic resonance imaging (fMRI) studies have reported partially differential patterns of activation in youth and adults diagnosed with MDD that may be attributable to age or length of illness.

Methods

Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed through November 2023 and selected 135 primary studies (N = 6391) based on the following inclusion criteria: 1) task-based fMRI activation, 2) voxelwise whole-brain analyses, and 3) comparison between participants diagnosed with MDD and age-matched healthy control participants (HCs). We used multilevel kernel density analysis with ensemble thresholding (p < .05–.0001, false discovery rate corrected) to find activation differences between 1) youth with MDD and HCs, 2) youth and adults with MDD, 3) youth and adults with shorter-duration MDD, and 4) adults with longer- and shorter-duration MDD.

Results

Relative to adults with MDD, youth with MDD demonstrated significant patterns of differential activation in regions such as the subgenual anterior cingulate cortex (sgACC) and dorsolateral prefrontal cortex (dlPFC) (p < .0025). Second, after controlling for length of illness, relative to adults with shorter-duration MDD, youth demonstrated hypoactivation in regions such as the sgACC (p < .01). Lastly, when controlling for age, relative to adults with shorter-duration MDD, adults with longer-duration MDD demonstrated hypoactivation in regions such as the dlPFC (p < .05).

Conclusions

These findings underscore the importance of considering age and length of illness in developmental models of MDD and inform neural models and clinical interventions for depression.

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青少年和成人重度抑郁症：功能性磁共振成像研究的定量全脑荟萃分析。

背景：重度抑郁症（MDD）是一种高度流行的精神障碍，在青少年和成人中治疗成功率有限。功能性磁共振成像（fMRI）研究报告了被诊断为重度抑郁症的青年和成人的部分不同的激活模式，这可能归因于年龄或疾病的长短。方法：根据PRISMA指南，我们检索了PubMed至2023年11月，并根据以下纳入标准选择了135项主要研究（N = 6391）：(1)基于任务的fMRI激活，(2)体素全脑分析，(3)将诊断为MDD的参与者与年龄匹配的健康对照（hc）进行比较。我们使用集合阈值（P < 0.05 - 0.0001； fdr校正）的多水平核密度分析来发现(1)MDD青年患者和hc患者、(2)MDD青年患者和成人患者、(3)病程较短的MDD青年患者和(4)病程较长和较短的MDD成人患者之间的激活差异。结果：与成年MDD患者相比，青少年MDD患者在亚掌前扣带皮层（sgACC）和背外侧前额叶皮层（dlPFC）等区域表现出显著的差异激活模式；P < 0.0025)。其次，在控制病程长短后，相对于病程较短的MDD患者，青少年表现出sgACC等区域的低激活（P < 0.01）。最后，当控制年龄时，相对于持续时间较短的MDD患者，持续时间较长的MDD患者在dlPFC等区域表现出低激活（P < 0.05）。结论：这些发现强调了在重度抑郁症的发育模型中考虑年龄和病程的重要性，并为抑郁症的神经模型和临床干预提供了信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.