Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity

IF 4.9 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2026-08-01 Epub Date: 2026-01-13 DOI:10.1016/j.bpsc.2025.12.014

Sophia H. Blyth, Lauren D. Hill, Anna Huang, Neil D. Woodward, Baxter P. Rogers, Simon Vandekar, Heather Burrell Ward

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引用次数: 0

Abstract

Background

Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There is limited research on triple-network connectivity (DMN, ECN, SN) in adolescents who use substances.

Methods

In typically developing youth from the Philadelphia Neurodevelopmental Cohort (PNC), regression models were used to examine relationships between alcohol and marijuana use and triple-network connectivity (n = 520), while adjusting for age, sex, maternal education, and head motion. In individuals with neurocognitive and substance use data (n = 4197), regression models were used to examine relationships with executive control.

Results

Alcohol use was not associated with any connectivity measures after false discovery rate correction. Higher marijuana use was associated with higher DMN-ECN connectivity (F_2,507 = 5.08, p = .0066, q = .039). Higher alcohol use was associated with better working memory (p = .020), mental flexibility (p < .0001), attention (p = .019), and executive efficiency (p = .0015) and accuracy (p = .00044), which may have been due to other socioeconomic factors. Marijuana use was not associated with neurocognitive performance.

Conclusions

In typically developing youth, marijuana use was associated with DMN-ECN connectivity, while alcohol use was associated with neurocognitive performance. Future research should use interventions targeting the DMN, ECN, and SN to interrogate relationships between connectivity, cognitive performance, and substance use.

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青少年大麻和酒精使用、神经认知表现和三网络静息状态连通性之间的关系。

背景：青少年药物使用与自杀、过量和执行功能障碍的风险增加有关。酒精和大麻是年轻人中使用最多的两种物质。药物使用与默认模式网络（DMN）、执行控制网络（ECN）和显著性网络（SN）之间的静息状态网络连接功能障碍和执行功能障碍有关。关于青少年使用物质的三网络连通性（DMN， ECN， SN）的研究有限。方法：在来自费城神经发育队列的典型发育青年中，使用回归模型检查酒精和大麻使用与三网络连接之间的关系（n=520），调整年龄，性别，母亲教育程度和头部运动。在具有神经认知和物质使用数据的个体中（n=4197），使用回归模型来检查与执行控制的关系。结果：FDR校正后，酒精使用与任何连通性测量无关。大麻使用越多，DMN-ECN连通性越高（F(2,507) = 5.08, p = 0.0066, q = 0.039）。结论：在典型发育的青少年中，大麻的使用与DMN-ECN连接有关，而酒精的使用与神经认知表现有关。未来的研究应该使用针对DMN、ECN和SN的干预措施来探究连通性、认知表现和物质使用之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.