[Bioactive substances delivery for bone repair via nanocomposites: advantages, mechanisms, and emerging trends].

Q3 Medicine

中国修复重建外科杂志 Pub Date : 2026-01-15 DOI:10.7507/1002-1892.202511049

Yanming Ma, Zhipo Du, Jianbo Wang, Xiaoming Li

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Abstract

Objective: The advantages, mechanisms, and advances in nanocomposites for delivering bioactive substances in bone tissue engineering were systematically reviewed.

Methods: This review provides a comprehensive analysis by conducting an in-depth retrieval of relevant literature and integrating it with related work from our research team.

Results: Capitalizing on their inherent size effects and tunable structures, nanocomposites exhibit high drug-loading capacity and controlled/targeted delivery, allowing for the co-delivery of diverse molecules. This smart delivery capability, responsive to specific pathological or external cues, facilitates on-demand precision release to execute multiple therapeutic functions, including osteogenesis, antibacterial action, and immunomodulation.

Conclusion: Nanocomposites demonstrate high delivery efficiency and controlled release kinetics, with the potential for future clinical translation of their multi-signal responsive and spatiotemporally precise drug release capabilities.

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[通过纳米复合材料输送生物活性物质用于骨修复：优势、机制和新兴趋势]。

目的：系统综述了纳米复合材料在骨组织工程中传递生物活性物质的优点、机理及研究进展。方法：深入检索相关文献，结合课题组相关工作，进行综合分析。结果：利用其固有的尺寸效应和可调结构，纳米复合材料表现出高载药能力和可控/靶向递送，允许多种分子的共同递送。这种智能递送能力，对特定的病理或外部线索作出反应，促进按需精确释放，以执行多种治疗功能，包括成骨，抗菌作用和免疫调节。结论：纳米复合材料具有较高的释药效率和控释动力学，具有多信号响应和时空精准释药的临床应用潜力。

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