Detriment of mycotoxin contamination in feed and nutrition-based prevention and control strategies: A review

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2026-04-01 Epub Date: 2026-01-13 DOI:10.1016/j.toxicon.2026.108996

Shijie Fan, Kunru Teng, Jiefeng Li, Beibei He, Aike Li, Weiwei Wang, Jing Zhang

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Abstract

The health of humans and livestock is significantly compromised by the pervasive and serious issue of mycotoxin contamination in crops. Exploring ways to eliminate mycotoxin contamination is a global concern. In vivo biological prevention and treatment of mycotoxin damage demand a comprehensive understanding of its harm mechanisms, which is essential for developing comprehensive strategies. This study aimed to systematically review the mechanisms by which mycotoxin contamination damages the organism, causing oxidative stress, cellular apoptosis, autophagy, ferroptosis, and via the gut–liver axis, gut–testis axis, and gut–immune axis, causing damage to multiple organs. Further, we explored a range of biological control measures, showing that supplementing diets and animal feed with plant extracts, trace elements, probiotics, and other additives effectively mitigates the damage caused by mycotoxin exposure. This review examines the feasibility and limitations of combined strategies utilizing trace element selenium, probiotics, and plant extracts, aiming to provide a promising approach for the prevention and control of mycotoxin contamination.

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饲料中霉菌毒素污染危害及基于营养的防控策略综述。

农作物中普遍存在的严重霉菌毒素污染问题严重损害了人类和牲畜的健康。探索消除霉菌毒素污染的方法是全球关注的问题。真菌毒素损伤的体内生物预防和治疗需要全面了解其危害机制，这对于制定综合策略至关重要。本研究旨在系统回顾霉菌毒素污染损害机体的机制，引起氧化应激、细胞凋亡、自噬、铁凋亡，并通过肠-肝轴、肠-睾丸轴和肠-免疫轴引起多脏器损伤。此外，我们探索了一系列生物防治措施，表明在饲料和动物饲料中添加植物提取物、微量元素、益生菌和其他添加剂可以有效减轻霉菌毒素暴露造成的损害。本文综述了微量元素硒、益生菌和植物提取物组合策略的可行性和局限性，旨在为真菌毒素污染的预防和控制提供一条有前景的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.