Evaluation of tetrahydrocurcumin-loaded hybrid calcium carbonate microcrystals for enhanced collagen synthesis

IF 4.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Process Biochemistry Pub Date : 2026-03-01 Epub Date: 2026-01-13 DOI:10.1016/j.procbio.2026.01.008

Ee Taek Hwang , Yeahwa Yoon , Ka Ram Kim , Jinhee Jeong , Jung Soo Kim , Dongwon Kim , Seong-Wook Seo , In-Soo Yoon

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引用次数: 0

Abstract

Plant-derived natural product-encapsulated organic–inorganic hybrid materials have shown promise as biologically active agents for health. Here, we extend our previous work by investigating the collagen synthesis activity and stability of tetrahydrocurcumin (THC) in amphiphilic copolymer-incorporated calcium carbonate biomineral formulations, offering a novel comparison with curcumin (CUR). The encapsulated THC preserved over 90 % of its initial concentration over four weeks under different storage conditions, confirming its high stability. Interestingly, THC induced 1.58- and 1.55-fold higher COL1A1 expression in normal human dermal fibroblasts (NHDFs) than CUR, enhancing collagen synthesis–related gene expression when 500 and 1000 µg mL⁻¹ hybrid microcrystals were used. These findings contrast with general assumptions that CUR exhibits superior therapeutic effects, illustrating the challenges in predicting the effectiveness of encapsulation technologies. This is the first study to systematically compare the encapsulation and biological efficiencies of CUR and THC in organic–inorganic hybrid materials, contributing to the broader field of natural product-based therapeutics.

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负载四氢姜黄素的杂化碳酸钙微晶促进胶原合成的评价

植物源性天然产品包封的有机-无机杂化材料已显示出作为健康生物活性剂的前景。在这里，我们扩展了之前的工作，研究了两亲共聚物-碳酸钙生物矿物配方中四氢姜黄素（THC）的胶原合成活性和稳定性，并与姜黄素（CUR）进行了新的比较。包封后的四氢大麻酚在不同的储存条件下保存了4周以上，其浓度保持在初始浓度的90 %以上，证实了其高稳定性。有趣的是，当使用500和1000 µg mL−1杂交微晶时，THC诱导正常人真皮成纤维细胞（NHDFs）中COL1A1的表达比CUR高1.58倍和1.55倍，增强胶原合成相关基因的表达。这些发现与一般认为CUR具有优越的治疗效果的假设形成对比，说明了预测包封技术有效性的挑战。这是第一个系统地比较有机-无机杂化材料中CUR和THC的包封性和生物效率的研究，为更广泛的天然产物治疗领域做出了贡献。

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来源期刊

Process Biochemistry 生物-工程：化工

CiteScore

8.30

自引率

4.50%

发文量

374

审稿时长

53 days

期刊介绍： Process Biochemistry is an application-orientated research journal devoted to reporting advances with originality and novelty, in the science and technology of the processes involving bioactive molecules and living organisms. These processes concern the production of useful metabolites or materials, or the removal of toxic compounds using tools and methods of current biology and engineering. Its main areas of interest include novel bioprocesses and enabling technologies (such as nanobiotechnology, tissue engineering, directed evolution, metabolic engineering, systems biology, and synthetic biology) applicable in food (nutraceutical), healthcare (medical, pharmaceutical, cosmetic), energy (biofuels), environmental, and biorefinery industries and their underlying biological and engineering principles.