Two cases of rare multinodular vacuolated neuronal tumors (MVNT)

Abstract

Multinodular vacuolar neurocytoma (MVNT) is a relatively uncommon benign neuroepithelial tumor with fewer than 200 documented cases in the literature to date^1,9. The present report details two cases of frontal lobe MVNT. A 37-year-old female patient incidentally revealed a left frontal cingulate lesion (previously misdiagnosed as enlarged perivascular spaces [PVSs]), with no history of seizures, trauma, or family history of tumours. The second case study concerned a 53-year-old female patient with a two-year history of right frontal lobe lesions and a one-year history of seizures, which were controlled with oxcarbazepine. The two tumours exhibited typical MVNT imaging features: T1-weighted low signal intensity (lower than adjacent gray/white matter signal), T2-weighted high signal intensity (approaching cerebrospinal fluid signal), T2-FLAIR non-suppressed high signal intensity, and no contrast enhancement. No peritumoral edema or mass effect was observed. No peritumoral edema or mass effect. Follow-up (3–24 months) confirmed lesion stability. In this case report, we aim to raise awareness of the disease and avoid misdiagnosis and overtreatment.