Self-assembled cyclodextrin-porphyrin nanoplatform for synergistic chemo-phototherapy and targeted delivery of camptothecin against breast cancer

IF 9.5 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chinese Chemical Letters Pub Date : 2026-04-01 Epub Date: 2025-09-25 DOI:10.1016/j.cclet.2025.111901

Jiaojiao Yang , Shaokun Yang , Wei Cheng , Jie Wu , Haijing Qu , Han Chen , Zhiran Duan , Yuqing Pan , Ning Wang , Chao Wang , Jian Gao , Bai Xiang , Xiangdong Xue

{"title":"Self-assembled cyclodextrin-porphyrin nanoplatform for synergistic chemo-phototherapy and targeted delivery of camptothecin against breast cancer","authors":"Jiaojiao Yang , Shaokun Yang , Wei Cheng , Jie Wu , Haijing Qu , Han Chen , Zhiran Duan , Yuqing Pan , Ning Wang , Chao Wang , Jian Gao , Bai Xiang , Xiangdong Xue","doi":"10.1016/j.cclet.2025.111901","DOIUrl":null,"url":null,"abstract":"<div><div>The management of breast cancer remains clinically intractable, driven by its highly invasive behavior and limited susceptibility to conventional treatments. In this study, we engineered an innovative cyclodextrin-porphyrin co-assembled nanoplatform (CT NPs) to enable multimodal breast cancer therapy. By successfully encapsulating camptothecin (CPT) within this nanocarrier, the system (CTC NPs) achieved synergistic chemo-phototherapeutic efficacy through dual-modality action. The highly biocompatible cyclodextrin carrier significantly improved the physicochemical characteristics of CPT. <em>In vivo</em> studies revealed that CTC NPs effectively evaded clearance by the reticuloendothelial system, overcame the defect of premature drug leakage, and exhibited superior tumor targeting and infiltration capabilities. Under near-infrared (NIR) laser irradiation, CTC NPs can simultaneously induce localized hyperthermia and produce reactive oxygen species (ROS), thereby achieving efficient tumor ablation. In 4T1 tumor-bearing mice, CTC NPs exhibited targeted, safe, and highly potent anti-tumor efficacy, significantly suppressing both primary tumor progression (tumor suppression rate > 95 %) and metastatic dissemination. In summary, this integrated nanoplatform establishes a novel theranostic paradigm for synergistic chemo-phototherapy against triple-negative breast cancer (TNBC), achieving precise tumor ablation through NIR-triggered drug release and real-time imaging guidance.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111901"},"PeriodicalIF":9.5000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Chemical Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1001841725010794","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

The management of breast cancer remains clinically intractable, driven by its highly invasive behavior and limited susceptibility to conventional treatments. In this study, we engineered an innovative cyclodextrin-porphyrin co-assembled nanoplatform (CT NPs) to enable multimodal breast cancer therapy. By successfully encapsulating camptothecin (CPT) within this nanocarrier, the system (CTC NPs) achieved synergistic chemo-phototherapeutic efficacy through dual-modality action. The highly biocompatible cyclodextrin carrier significantly improved the physicochemical characteristics of CPT. In vivo studies revealed that CTC NPs effectively evaded clearance by the reticuloendothelial system, overcame the defect of premature drug leakage, and exhibited superior tumor targeting and infiltration capabilities. Under near-infrared (NIR) laser irradiation, CTC NPs can simultaneously induce localized hyperthermia and produce reactive oxygen species (ROS), thereby achieving efficient tumor ablation. In 4T1 tumor-bearing mice, CTC NPs exhibited targeted, safe, and highly potent anti-tumor efficacy, significantly suppressing both primary tumor progression (tumor suppression rate > 95 %) and metastatic dissemination. In summary, this integrated nanoplatform establishes a novel theranostic paradigm for synergistic chemo-phototherapy against triple-negative breast cancer (TNBC), achieving precise tumor ablation through NIR-triggered drug release and real-time imaging guidance.

Abstract Image

查看原文本刊更多论文

自组装环糊精-卟啉纳米平台协同化疗-光疗和靶向递送喜树碱对抗乳腺癌

乳腺癌的治疗仍然是临床上难以解决的，这是由于其高度侵袭性行为和对传统治疗的有限易感性。在这项研究中，我们设计了一种创新的环糊精-卟啉共组装纳米平台（CT NPs），以实现多模式乳腺癌治疗。通过成功地将喜树碱（CPT）包封在这种纳米载体中，该系统（CTC NPs）通过双模态作用实现了化学-光疗的协同效果。高生物相容性的环糊精载体显著改善了CPT的理化特性。体内研究表明，CTC NPs有效逃避网状内皮系统的清除，克服了药物过早渗漏的缺陷，表现出优越的肿瘤靶向和浸润能力。在近红外（NIR）激光照射下，CTC NPs可以同时诱导局部热疗和产生活性氧（ROS），从而实现有效的肿瘤消融。在4T1荷瘤小鼠中，CTC NPs表现出靶向、安全、高效的抗肿瘤功效，显著抑制原发肿瘤进展（肿瘤抑制率>； 95% %）和转移性扩散。总之，这个集成的纳米平台为三阴性乳腺癌（TNBC）的协同化疗光疗建立了一个新的治疗范例，通过nir触发的药物释放和实时成像引导实现精确的肿瘤消融。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.