The interleukin-1 receptor antagonist gene VNTR polymorphism confers a genetic contribution to the risk of immune thrombocytopenia purpura: A systematic review and meta-analysis

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI:10.1016/j.cyto.2026.157112

Huifang Wei , Yuyang Xie , Qingyang Huai , Zixiao Hua , Xinyu Yang , Lingxi Chen , Youyi Kong , Wen Xue , Caiming Zhao , Shangshang Gao , Xiaoqin Yang

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Abstract

The purpose of this systematic review and meta-analysis was to summarize the existing evidence of the IL1RN variable number (usually two to six) of tandem repeat (VNTR) polymorphism in modulating the susceptibility to immune thrombocytopenia purpura (ITP), with the aim of clarifying its potential as a genetic marker for disease risk stratification. An extensive literature review was performed utilizing the Cochrane Library, NCBI PubMed, and Clarivate Web of Science databases, covering publications up to October 11, 2025. R language was employed to perform pooled estimation and present the results. The odds ratios and corresponding 95% confidence intervals were estimated to assess the strength of the effect. A total of 12 case-control studies comprising 770 ITP cases and 1424 controls were integrated for further synthetic analyses. Summary estimates in all genetic models suggested that the individuals carrying the variant with two repeats are more susceptible to this hematologic disorder. When stratified by geographic region, only the pooled estimates for Latin American and North African countries were statistically significant. No significant publication bias was evident. In conclusion, this meta-analysis indicated that the IL1RN VNTR polymorphism was significantly associated with ITP susceptibility, particularly in Latin American and North African populations.

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白细胞介素-1受体拮抗剂基因VNTR多态性与免疫性血小板减少性紫癜的遗传风险有关：一项系统综述和荟萃分析。

本系统综述和荟萃分析的目的是总结现有的IL1RN串联重复序列（VNTR）可变数目（通常为2至6个）多态性在调节免疫性血小板减少性紫癜（ITP）易感性中的证据，目的是阐明其作为疾病风险分层遗传标记的潜力。我们利用Cochrane图书馆、NCBI PubMed和Clarivate Web of Science数据库进行了广泛的文献综述，涵盖了截至2025年10月11日的出版物。采用R语言进行池估计并给出结果。估计比值比和相应的95%置信区间来评估效果的强度。共纳入了12项病例对照研究，包括770例ITP病例和1424例对照，用于进一步的综合分析。所有遗传模型的总结估计表明，携带两个重复变体的个体更容易患这种血液病。当按地理区域分层时，只有拉丁美洲和北非国家的汇总估计值具有统计学意义。没有明显的发表偏倚。总之，这项荟萃分析表明，IL1RN VNTR多态性与ITP易感性显著相关，特别是在拉丁美洲和北非人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.