G. Z. Mikhailova, L. G. Bobyleva, A. G. Bobylev, T. A. Uryupina, S. N. Udaltsov, R. H. Ziganshin, L. I. Kramarova, I. M. Vikhlyantsev
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引用次数: 0
Abstract
The effect of the Thr–Ser–Lys–Tyr peptide isolated from the brain of the obligate hibernating long-tailed ground squirrel Urocitellus undulatus (formerly Citellus undulatus, Spermophilus undulatus) on the polymerization/depolymerization of actin in vitro was studied by electron microscopy. Upon incubation of the peptide with globular (monomeric) actin at concentrations of 0.1 mg/mL (at a ratio of 1 : 1), the formation of single filaments of actin was observed. When the peptide was added to the formed actin filaments, no effects were observed, in particular, actin depolymerization. The possible involvement of the peptide in the polymerization of actin in vivo and a possible contribution to the restoration of the functional activity of the central nervous system after the hibernating animal leaves the state of hypothermia are discussed.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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