The Effect of Gel Materials Based on Collagen and Taxifolin Derivatives on the Healing of Burn Wounds Induced by Acetic Acid

Abstract

The aim of this work was to evaluate the effects of gel materials containing taxifoline pentaglutarate and a conjugate of taxifolin with glyoxylic acid on the healing of skin wounds caused by acetic acid. It was shown that collagen materials containing polyphenols accelerated re-epithelialization and formation of granulation tissue compared with the control (collagen alone). The data obtained indicate that taxifolin derivatives can be considered as promising agents that not only cross-link collagen molecules, but also have a wound-healing effect. In turn, materials based on collagen and these polyphenols can be considered as dual purpose materials, that is, as wound-healing agents and as a delivery system of biologically active substances to the area of injury.